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Table 3 Unadjusted AED costs per patient who received AEDs

From: Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs

Category

All

No Seizure

EEG Seizure

Clinical Seizure

 

n

median [IQR] cost

n

median [IQR] cost

n

median [IQR] cost

n

median [IQR] cost

All AEDs

1252

$89.90 [24.52, 265.84]

563

$34.13 [11.38, 100.76]

464

$229.39 [93.73, 511.49]

255

$101.15 [38.91, 209.57]

Phenobarbital

739

$96.96 [35.53, 206.04]

107

$32.32 [13.81, 97.86]

437

$129.79 [59.86, 262.06]

195

$64.64 [24.14, 142.23]

Phenytoin/Fosphenytoin

118

$67.71 [15.46, 238.53]

3

$36.85 [29.78, 259.06]

97

$69.59 [15.46, 238.53]

18

$70.25 [25.91, 123.94]

Levetiracetam

128

$197.62 [59.25, 453.18]

10

$69.82 [13.84, 80.51]

98

$240.09 [105.10, 534.20]

20

$53.39 [21.48, 163.88]

Benzodiazapines

1010

$34.13 [11.38, 91.02]

525

$26.30 [11.37, 82.54]

328

$45.51 [17.33, 102.39]

157

$34.13 [15.39, 91.07]

Other (oxcarbazepine, gabapentin, topiramate, valproate)

19

$102.94 [26.49, 354.27]

3

$19.18 [6.62, 56.29]

15

$134.22 [51.21, 379.45]

1

$26.49 [26.49, 26.49]

  1. Abbreviations: AED anti-epileptic drug, EEG electroencephalographic, IQR interquartile range