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Table 2 Viral load and resistance profiles of children with virological failure (VL > 1000 copies/mL)

From: High level of treatment failure and drug resistance to first-line antiretroviral therapies among HIV-infected children receiving decentralized care in Senegal

Variables n/N tested % %
Viral load (VL)
 VL ≥ 3 log10 320/498 64  
  3 log10 ≤ VL ≤ 3.7 log10 120/320   37.5
  3.7 log10 < VL ≤ 4 log10 40/320   12.5
  4 log10 < VL ≤ 4.7 log10 100/320   31.25
  4.7 log10 < VL ≤ 5 log10 27/320   8.44
  5 > VL log10 33/320   10.31
 Median VL = 4 log10    
Genotypes performed 304/320   95
Frequency of drug-resistant virus
 Resistance to at least one ART 263/304 86.5  
  Resistance to NRTIs only 5/263   1.9
  Resistance to NNRTIs only 60/263   22.8
  Resistance to NRTIs+NNRTIs 197/263   74.9
  Resistance to NRTIs+NNRTIs+PIs 1/263   0.4
Frequency of drug resistance to the different drugs
 AZT 90/263   34.22
 d4T 93/263   35.36
 3TC/FTC 195/263   74.14
 ABC 165/263   62.73
 ddI 18/263   6.84
 TDF 43/263   16.34
 EFV 238/263   90.49
 NVP 253/263   96.19
 ETRa 125/263   47.52
 RPVa 136/263   51.71
Predicted resistance to the current regimen (3 drugs)
 No resistance 5/263   1.9
 1 out of 3 drugs 66/263   25.09
 2 out of 3 drugs 106/263   40.3
 3 out of 3 drugs 86/263   32.69
  1. aDrug not given in the current ART regimen
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