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Table 4 Predicting of first line HAART failure in HIV infected children with HIV/AIDS treated in HIV clinics at Tikur Anbessa Hospital, Addis Ababa, Ethiopia from April 1 to May 15, 2018.(n = 318)

From: Predictors of treatment failure, time to switch and reasons for switching to second line antiretroviral therapy in HIV infected children receiving first line anti-retroviral therapy at a Tertiary Care Hospital in Ethiopia

Independent variable

Treatment Failure (%)

Treatment Success (%)

Odds Ratio (95% CI)

Adjusted Odds Ratio (95%CI)a

Primary Care Taker

 Both parents

8(8.08)

91(91.92)

1.00

 

 Other Care takers

64(29.22)

155(70.77)

3.72 (1.61–8.61)

2.72 (1.05–7.06)*

Serology of Care Taker

 Positive

32(16.90)

157(83.06)

1.00

 

 Negative

15(29.41)

36(70.50)

2.27 (1.03–4.99)

2.69 (1.03–7.03)*

 Unknown

25(32.05)

53(67.95)

2.12 (1.05–4.27)

2.26 (0.93–5.49)

Disclosure to the Child

 Disclosed

57(20.2)

225(79.7)

1.00

 

 Not disclosed

15(41.6)

21(58.40)

2.48 (1.09–5.65)

1.41 (0.55–3.65)

Base Line WHO Stage

 Stage 1 and 2

20(10.9)

162(89.01)

1.00

 

 Stage 3 and 4

52(38.2)

84(61.70)

5.33 (2.73–10.40)

3.64 (1.76–7.56)*

Age at initiation of HAART

  < =11 month

37(40.6)

54(59.30)

1.00

 

 12–34 months

14(22.22)

49(77.78)

0.39 (0.17–0.88)

0.40 (0.16–0.99)*

 35–59 months

14(26.92)

38(73.08)

0.49 (0.21–1.14)

0.55 (0.21–1.43)

  > = 60 months

7(6.25)

105(93.75)

0.07 (0.02–0.21)

0.07 (0.02–0.24)*

  1. *- Variables that showed a p-value of less than 0.05 on the multiple logistic regression analysis
  2. aAdjusted odds ratio – adjusted for primary care taker, serology of care taker, disclosure to the child, base line WHO stage and age at the initiation of HAART