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Table 4 Predicting of first line HAART failure in HIV infected children with HIV/AIDS treated in HIV clinics at Tikur Anbessa Hospital, Addis Ababa, Ethiopia from April 1 to May 15, 2018.(n = 318)

From: Predictors of treatment failure, time to switch and reasons for switching to second line antiretroviral therapy in HIV infected children receiving first line anti-retroviral therapy at a Tertiary Care Hospital in Ethiopia

Independent variable Treatment Failure (%) Treatment Success (%) Odds Ratio (95% CI) Adjusted Odds Ratio (95%CI)a
Primary Care Taker
 Both parents 8(8.08) 91(91.92) 1.00  
 Other Care takers 64(29.22) 155(70.77) 3.72 (1.61–8.61) 2.72 (1.05–7.06)*
Serology of Care Taker
 Positive 32(16.90) 157(83.06) 1.00  
 Negative 15(29.41) 36(70.50) 2.27 (1.03–4.99) 2.69 (1.03–7.03)*
 Unknown 25(32.05) 53(67.95) 2.12 (1.05–4.27) 2.26 (0.93–5.49)
Disclosure to the Child
 Disclosed 57(20.2) 225(79.7) 1.00  
 Not disclosed 15(41.6) 21(58.40) 2.48 (1.09–5.65) 1.41 (0.55–3.65)
Base Line WHO Stage
 Stage 1 and 2 20(10.9) 162(89.01) 1.00  
 Stage 3 and 4 52(38.2) 84(61.70) 5.33 (2.73–10.40) 3.64 (1.76–7.56)*
Age at initiation of HAART
  < =11 month 37(40.6) 54(59.30) 1.00  
 12–34 months 14(22.22) 49(77.78) 0.39 (0.17–0.88) 0.40 (0.16–0.99)*
 35–59 months 14(26.92) 38(73.08) 0.49 (0.21–1.14) 0.55 (0.21–1.43)
  > = 60 months 7(6.25) 105(93.75) 0.07 (0.02–0.21) 0.07 (0.02–0.24)*
  1. *- Variables that showed a p-value of less than 0.05 on the multiple logistic regression analysis
  2. aAdjusted odds ratio – adjusted for primary care taker, serology of care taker, disclosure to the child, base line WHO stage and age at the initiation of HAART