Evaluation of systemic inflammatory response syndrome-negative sepsis from a Chinese regional pediatric network

BMC Pediatrics

Table 2 Medications in the three groups

	Sepsis^c	SS^c	SNS	p
Cases, n	1377	153^d	76
Antimicrobial therapy
pre-hospital, n (%)	1054 (76.5)	123 (80.9)	65 (86.7)	0.101
during, n (%)	1354 (98.3)	148 (96.7)	76 (100.0)	0.177
within 2 h, n (%)	1243 (91.7)	132 (88.6)	69 (90.8)	0.422
time, days mean ± SD	8.4 ± 4.6	10.3 ± 7.9^a	12.4 ± 5.5^ab	0.000
Other therapy
GS, n (%)	500 (36.4)	120 (79.5)^a	57 (75.0)^a	0.000
VA, n (%)	23 (0.5)	103 (67.3)^a	46 (60.5)^a	0.000
IA, n (%)	3 (0.2)	92 (60.1)^a	63 (82.9)^ab	0.000
Sedatives, n (%)	100 (7.3)	109 (71.2)^a	59 (77.6)^a	0.000
IVIG, n (%)	52 (3.8)	49 (32.2)^a	19 (25.0)^a	0.000

Group definition: Sepsis, sepsis; SS, severe sepsis; SNS, SIRS-negative sepsis
Definition of abbreviations: pre-hospital, antimicrobial therapy was started prior to admission; during, antimicrobial therapy was given during hospitalization; within 2 h, intravenous antimicrobial therapy was started within 2 h of recognizing sepsis; time, the entire period of antimicrobial treatment; GS, glucocorticosteroids; VA, vasoactive agents; IA, inotropes; IVIG, intravenous immunoglobulin
Statistical analysis: ^a p < 0.01 vs, S; ^b p < 0.01 vs, SS
^cValues are taken from reference [15]; ^dNumbers include 32 septic shock

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