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Table 2 Characteristics of different forms of nitric oxide synthase [14, 15]

From: Hypertrophic pyloric stenosis following persistent pulmonary hypertension of the newborn: a case report and literature review

Type

Gene(s)

Location

Function

Neuronal NOS

(nNOS)

NOS 1

Chromosome 12

(12q24.22)

Nervous tissue

Skeletal muscle type II

Cell communication:

Neurotransmission

Skeletal muscle contraction

Sexual function

Body fluid homeostasis

Inducible NOS

(iNOS)

NOS 2

Chromosome 17

(17q11.2)

Immune system

Cardiovascular system

Immune defense against pathogens:

Inflammation

Infection

Malignant diseases

Blood pressure regulation

Endothelial NOS

(eNOS)

NOS 3

Chromosome 7

(7q36.1)

Endothelium

Cardiovascular homeostasis:

Vasodilation

Inhibition of platelet aggregation

and adhesion

Inhibition of vascular inflammation

  1. NOS nitric oxide synthase