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Table 2 Clinical characteristics of newborns enrolled in the study (n = 51)

From: Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants

Variable

Good outcome

(n = 35)

Poor outcome

(n = 16)

p value

Male sex

19 (51%)

12 (75%)

0.1365

Gestational age (weeks)

39 [38; 40]

38 [37; 40]

0.0536

Birth weight (g)

3261 ± 577

3128 ± 537

0.4379

Apgar 1′

2 [1; 4]

1 [0; 2]

0.0091

Apgar 5′

5 [4; 7]

3 [2; 4]

0.0002*

Apgar 10′

6 [5; 8]

4 [2; 4]

0.0005*

Lowest pH < 1 h of age

7.21 [6.98; 7.28]

7.10 [7.00; 7.20]

0.1643

Highest BD < 1 h of age

14.1 ± 5.9

17.1 ± 4.6

0.0860

Onset of hypothermia (h)

1.8 [1.4; 3.1]

2.1 [1.4; 3.3]

0.6309

Severity of encephalopathy (severe)#

31 (89%)

15 (94%)

> 0.9999

Clinical or aEEG seizures (<  24 h)

28 (80%)

14 (88%)

0.7012

Abnormal aEEG pattern (BS, LV, FT)

31 (88%)

12 (75%)

0.2396

aEEG normalization (CNV, DNV) < 72 h

22 (63%)

5 (31%)

0.0681

aEEG normalization time (h)

30 [12; 47]

60 [42; 68]

0.1381

Age at MR scan (h)

25 [14; 49]

30 [16; 54]

0.6625

Abnormalities on MR Imaging (T1/T2 weighted imaging or DWI)

13 (37%)

11 (69%)

0.0681

Death

0

9 (56%)

NA†

  1. Data shown as median [IQR], mean ± SD or percentage. Good outcome is defined as both MDI (Mental Developmental Index) and PDI (Psychomotor Developmental Index) ≥ 70 achieved on Bayley II test, poor outcome is defined as either MDI or PDI < 70 OR death (< 28 days of age OR > 28 days of age associated with HIE)
  2. BD base deficit, aEEG amplitude-integrated electroencephalography, CNV continuous normal voltage, DNV discontinuous normal voltage, BS burst suppression, LV low voltage, FT flat trace, DWI diffusion weighted imaging
  3. * represents significant results surviving Bonferroni-correction (p < 0.0014)
  4. # moderate encephalopathy: 6 h normal aEEG pattern (CNV, DNV) AND Sarnat stage 1–2, severe encephalopathy: 6 h abnormal aEEG pattern (BS, LV, FT) OR Sarnat stage 3 [21]
  5. NA† (not applicable) represents statistical significance not applicable as death was included in the definition of the poor outcome group
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BMC Pediatrics

ISSN: 1471-2431

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