Table 5 Combined genotype frequencies of MTHFR C677T, A1298C and SLC19A1 G80A among controls and CTD cases
Genotype | Controls (n = 234) | CTD (N = 193) | p-Value | |
|---|---|---|---|---|
No. (%) | No. (%) | OR (95% CI) | ||
MTHFR C677T and A1298C combinations | ||||
677CC, 1298AA | 32(13.68) | 23(11.92) | 1.00 | |
677CC, 1298 AC + CC | 51(21.79) | 42(21.76) | 1.15(0.60–2.23) | 0.6921 |
1298AA, 677CT + TT | 78(33.33) | 34(17.62) | 0.61(0.32–1.17) | 0.1421 |
Either one variant genotype | 129(55.13) | 76(39.38) | 0.82(0.44–1.49) | 0.5199 |
Both variant genotypes | 73(31.20) | 94(48.70) | 1.79(0.95–3.33) | 0.0623 |
MTHFR C677T and SLC19A1 G80A combinations | ||||
677CC, 80GG | 35(14.96) | 21(10.88) | 1.00 | |
677CC, 80AG + AA | 48(20.51) | 44(22.80) | 1.53(0.76–3.03) | 0.2196 |
80GG, 677CT + TT | 67(28.63) | 47(24.35) | 1.17(0.60–2.23) | 0.6410 |
Either one variant genotype | 115(49.15) | 91(47.15) | 1.32(0.72–2.44) | 0.3706 |
Both variant genotypes | 84(35.90) | 81(41.97) | 1.61(0.85–3.05) | 0.1327 |
MTHFR A1298C and SLC19A1 G80A combinations | ||||
1298AA, 80GG | 46(19.66) | 18(9.33) | 1.00 | |
1298AA, 80AG + AA | 64(27.35) | 39(20.21) | 1.56(0.79–3.14) | 0.1969 |
80GG, 1298 AC + CC | 56(23.93) | 50(25.91) | 2.28(1.18–4.53) | 0.0141* |
Either one variant genotype | 120(51.28) | 89(46.11) | 1.90(1.05–3.40) | 0.0382* |
Both variant genotypes | 68(29.06) | 86(44.56) | 3.23(1.71–6.02) | 0.0002* |
MTHFR C677T, A1298C and SLC19A1 G80A combinations | ||||
677CC, 1298AA, 80GG | 12(5.13) | 10(5.18) | 1.00 | |
677CC, 1298AA, 80AG + AA | 20(8.55) | 11(5.70) | 0.66(0.20–2.09) | 0.4646 |
677CC, 80GG, 1298 AC + CC | 23(9.83) | 11(5.70) | 0.57(0.18–1.77) | 0.3226 |
1298AA, 80GG, 677CT + TT | 34(14.53) | 10(5.18) | 0.35(0.11–1.06) | 0.0582 |
Either one variant genotype | 77(32.91) | 32(16.58) | 0.50(0.20–1.34) | 0.1400 |
677CC, 1298 AC + CC, 80AG + AA | 28(11.97) | 31(16.06) | 1.33(0.48–3.32) | 0.5704 |
677CT + TT, 1298AA, 80AG + AA | 44(18.80) | 26(13.47) | 0.71(0.26–1.78) | 0.4859 |
677CT + TT, 1298 AC + CC, 80GG | 33(14.10) | 39(20.21) | 1.42(0.54–3.52) | 0.4740 |
Either two variant genotypes | 105(44.87) | 96(49.74) | 1.10(0.48–2.67) | 0.8370 |
All variant genotypes | 40(17.09) | 55(28.50) | 1.65(0.66–4.40) | 0.2900 |