Table 4 Genotype frequencies among controls, TOF, PA/VSD, DORV, TGA, PTA and IAA cases
Genotype | Controls (n = 234) | TOF (n = 90) | p-Value | PA/VSD (n = 31) | p-Value | DORV (n = 35) | p-Value | TGA (n = 10) | p-Value | PTA (n = 14) | p-Value | IAA (n = 13) | p-Value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. (%) | No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | |||||||
MTHFR C677T | |||||||||||||||||||
CC | 83(35.47) | 31(34.44) | 1.00 | 13(41.94) | 1.00 | 9(25.71) | 1.00 | 2(20.00) | 1.00 | 6(42.86) | 1.00 | 4(30.77) | 1.00 | ||||||
CT | 120(51.28) | 32(35.56) | 0.71(0.41–1.24) | 0.2347 | 11(35.48) | 0.59(0.26–1.39) | 0.2130 | 13(37.14) | 0.99(0.40–2.39) | 0.9984 | 5(50.00) | 1.73(0.36–8.84) | 0.5140 | 4(28.57) | 0.46(0.14–1.80) | 0.2315 | 3(23.08) | 0.52(0.13–1.98) | 0.3906 |
TT | 31(13.25) | 27(30.00) | 2.33(1.18–4.39) | 0.0111* | 7(22.58) | 1.44(0.56–3.90) | 0.4749 | 13(37.14) | 3.87(1.55–9.32) | 0.0034* | 3(30.00) | 4.02(0.78–23.14) | 0.1120 | 4(28.57) | 1.79(0.54–6.38) | 0.3883 | 6(46.15) | 4.02(1.09–13.12) | 0.0297* |
CT + TT | 151(64.53) | 59(65.56) | 1.05(0.64–1.72) | 0.8625 | 18(58.06) | 0.76(0.36–1.59) | 0.4816 | 26(74.29) | 1.59(0.70–3.60) | 0.2565 | 8(80.00) | 2.20(0.52–10.46) | 0.3147 | 8(57.14) | 0.73(0.24–2.21) | 0.5757 | 9(69.23) | 1.24(0.38–3.72) | 0.7298 |
MTHFR A1298C | |||||||||||||||||||
AA | 110(47.01) | 27(30.00) | 1.00 | 11(35.48) | 1.00 | 10(28.57) | 1.00 | 4(40.00) | 1.00 | 3(21.43) | 1.00 | 2(15.38) | 1.00 | ||||||
AC | 67(28.63) | 33(36.67) | 2.01(1.11–3.70) | 0.0201* | 13(41.94) | 1.94(0.80–4.39) | 0.1255 | 12(34.29) | 1.97(0.85–4.87) | 0.1313 | 2(20.00) | 0.82(0.15–3.61) | 0.8222 | 7(50.00) | 3.83(1.00–13.90) | 0.0431* | 4(30.77) | 3.28(0.74–17.52) | 0.1543 |
CC | 57(24.36) | 30(33.33) | 2.14(1.14–3.88) | 0.0133* | 7(22.58) | 1.23(0.47–3.39) | 0.6869 | 13(37.14) | 2.51(1.00–6.13) | 0.0369* | 4(40.00) | 1.93(0.54–6.80) | 0.3575 | 4(28.57) | 2.57(0.67–10.43) | 0.2113 | 7(53.85) | 6.75(1.41–32.67) | 0.008* |
AC + CC | 124(52.99) | 63(70.00) | 2.07(1.22–3.50) | 0.0055* | 20(64.52) | 1.61(0.76–3.63) | 0.2261 | 25(71.43) | 2.22(1.02–4.61) | 0.0407* | 6(60.00) | 1.33(0.35–4.26) | 0.6635 | 11(78.57) | 3.25(0.97–11.09) | 0.0619 | 11(84.62) | 4.88(1.15–22.36) | 0.0258* |
SLC19A1 G80A | |||||||||||||||||||
GG | 102(43.59) | 29(32.22) | 1.00 | 13(41.94) | 1.00 | 15(42.86) | 1.00 | 3(30.00) | 1.00 | 3(21.43) | 1.00 | 5(38.46) | 1.00 | ||||||
AG | 82(35.04) | 35(38.89) | 1.62(0.93–2.87) | 0.0987 | 12(38.71) | 1.24(0.51–2.90) | 0.6163 | 10(28.57) | 0.89(0.38–2.06) | 0.7983 | 1(10.00) | 0.45(0.03–3.06) | 0.4786 | 5(35.71) | 2.24(0.57–8.62) | 0.2691 | 6(46.15) | 1.61(0.45–4.84) | 0.4416 |
AA | 50(21.37) | 26(28.89) | 1.63(0.88–2.99) | 0.1205 | 6(19.35) | 0.84(0.31–2.26) | 0.7387 | 10(28.57) | 1.21(0.51–2.85) | 0.6593 | 6(60.00) | 3.64(0.96–13.59) | 0.0593 | 6(42.86) | 3.64(0.96–13.59) | 0.0593 | 2(15.38) | 0.73(0.14–3.58) | 0.7094 |
AG + AA | 132(56.41) | 61(67.78) | 1.63(0.96–2.70) | 0.0618 | 18(58.06) | 1.07(0.51–2.22) | 0.8614 | 20(57.14) | 1.03(0.50–2.12) | 0.9350 | 7(70.00) | 1.80(0.49–6.53) | 0.3953 | 11(78.57) | 2.83(0.84–9.67) | 0.1031 | 8(61.54) | 1.24(0.38–3.44) | 0.7165 |
MTR A2756G | |||||||||||||||||||
AA | 87(37.18) | 33(36.67) | 1.00 | 13(41.94) | 1.00 | 10(28.57) | 1.00 | 2(20.00) | 1.00 | 3(21.43) | 1.00 | 5(38.46) | 1.00 | ||||||
AG | 120(51.28) | 46(51.11) | 1.01(0.59–1.70) | 0.9686 | 15(48.39) | 0.84(0.39–1.83) | 0.6585 | 21(60.00) | 1.52(0.70–3.29) | 0.3018 | 6(60.00) | 2.18(0.52–10.77) | 0.3373 | 11(78.57) | 2.66(0.78–9.10) | 0.1289 | 8(61.54) | 1.16(0.35–3.24) | 0.8003 |
GG | 27(11.54) | 11(12.22) | 1.07(0.50–2.37) | 0.8623 | 3(9.68) | 0.74(0.21–2.60) | 0.6609 | 4(11.43) | 1.29(0.42–4.40) | 0.6871 | 2(20.00) | 3.22(0.48–21.06) | 0.2295 | 0(0.00) | NA | NA | 0(0.00) | NA | NA |
AG + GG | 147(62.82) | 57(63.33) | 1.02(0.61–1.72) | 0.9318 | 18(58.06) | 0.82(0.39–1.71) | 0.6077 | 25(71.43) | 1.48(0.67–3.10) | 0.3226 | 8(80.00) | 2.37(0.56–11.26) | 0.2691 | 11(78.57) | 2.17(0.64–7.42) | 0.2338 | 8(61.54) | 0.95(0.29–2.64) | 0.9259 |
MTRR A66G | |||||||||||||||||||
AA | 75(32.05) | 36(40.00) | 1.00 | 14(45.16) | 1.00 | 12(34.29) | 1.00 | 3(30.00) | 1.00 | 2(14.29) | 1.00 | 4(30.77) | 1.00 | ||||||
AG | 116(49.57) | 46(51.11) | 0.83(0.48–1.38) | 0.4747 | 16(51.61) | 0.74(0.33–1.54) | 0.4423 | 11(31.43) | 0.59(0.26–1.36) | 0.2338 | 3(30.00) | 0.65(0.15–2.83) | 0.5966 | 9(64.29) | 0.29(0.73–13.68) | 0.1615 | 7(53.85) | 1.13(0.34–3.55) | 0.8478 |
GG | 43(18.38) | 8(8.89) | 0.39(0.17–0.88) | 0.026* | 1(3.23) | 0.12(0.01–0.71) | 0.021* | 12(34.29) | 1.74(0.75–4.03) | 0.2139 | 4(40.00) | 2.33(0.60–9.50) | 0.2719 | 3(21.43) | 2.62(0.51–15.07) | 0.2862 | 2(15.38) | 0.87(0.16–3.88) | 0.8773 |
AG + GG | 159(67.95) | 54(60.00) | 0.71(0.43–1.18) | 0.1769 | 17(54.84) | 0.57(0.27–1.19) | 0.1464 | 23(65.71) | 0.90(0.42–1.91) | 0.7921 | 7(70.00) | 1.10(0.29–4.00) | 0.8917 | 12(85.71) | 2.83(0.69–12.93) | 0.1629 | 11(84.62) | 1.06(0.44–3.81) | 0.9232 |