Skip to main content

Advertisement

Table 2 Selected laboratory dataa

From: Eleven percent intact PGM3 in a severely immunodeficient patient with a novel splice-site mutation, a case report

Analysis Ref interval Patient, at 24 months Unit
Platelets 150–350 456 ×  109 /L
Eosinophils 0.04–0.4 0.67 ×  109 cells/L
IgG 3.5–10.5 15 g/L
IgA 0.07–0.55 3.0 g/L
IgM 0.27–1.2 1.7 g/L
IgE < 13 12,000 kU/L
TREC (T-cell receptor excision circles) > 1500 1020 molecules/million cells
In vitro T cell proliferation (PHA, ConA, PPD, candida)   All low % of donors
FASCIA (T cell recall response, PHA, PWM, PPD, TT, candida, influenza, CMV, HSV, VZV)   All low for both CD4 + and CD8 + % of donors
Anti TSH receptor ab   +  
Anti TPO ab   +  
Absolute lymphocyte number 1.7–6.9 0.94 × 109 cells/L
CD3+cells T cells 0.9–4.5 0.60 ×  109 cells/L
CD3+CD4+ 0.62–0.86 0.39 × 109 cells/L
CD3+CD4+CCR7+45RA+ Naïve CD4+T cells 0.26–0.38 0.05 × 109 cells/L
CD3+CD4+CCR7+45RA+CD31+ CD4+ Recent thymic emigrants 0.12–0.24 0.03 × 109 cells/L
CD3+CD4+CCR7+45RA Central memory CD4+ T cells 0.20–0.34 0.13 ×  109 cells/L
CD3+CD4+CCR7+45RACD38+HLA-DR+ Activated central memory CD4+ T cells 0–1 4 ×  109 cells/L
CD3+CD4+CCR745RACD38+HLA-DR+ Activated effector memory CD4+ T cells 0–0.01 0.05 ×  109 cells/L
CD3+CD4+CCR7+45RACXCR3CCR6+ TH17 cells 0.06–0.10 0.02 × 109 cells/L
CD3+CD4+CCR4+CD25hiCD127low45RO Naïve Treg 0.02–0.02 < 0.01 ×  109 cells/L
CD3+CD8+ 0.25–0.49 0.18 ×  109 cells/L
CD3+CD8+CCR7+45RA+ Naïve CD8+ T cells 0.07–0.13 < 0.01 × 109 cells/L
CD3+CD8+CCR7+45RA Central memory CD8+ T cells 0.03–0.05 < 0.01 ×  109 cells/L
CD3+CD8+CCR745RACD38+HLADR+ Activated effector memory CD8+ T cells 0–0.01 0.05 × 109 cells/L
  1. Abbreviations found in the table: CMV Cytomegalo virus, ConA Concanavalin A, HSV Herpes simplex virus, PHA Phytohaemagglutinin, PPD Tuberculin antigen, PWM Pokeweed mitogen, TT Tetanus toxoid, VZV Varicella zoster virus, TSH Thyroid stimulating hormone, TPO Thyroperoxidase
  2. aSelected laboratory data with numbers outside of reference intervals, for a complete list of performed analyses see Additional file 1: Table S2. Elevated levels in bold, reduced levels in italic