Table 2 Selected laboratory data^a

Platelets

150–350

456

×  10⁹ /L

Eosinophils

0.04–0.4

0.67

×  10⁹ cells/L

IgG

3.5–10.5

15

g/L

IgA

0.07–0.55

3.0

g/L

IgM

0.27–1.2

1.7

g/L

IgE

< 13

12,000

kU/L

TREC

(T-cell receptor excision circles)

> 1500

1020

molecules/million cells

In vitro T cell proliferation

(PHA, ConA, PPD, candida)

All low

% of donors

FASCIA (T cell recall response, PHA, PWM, PPD, TT, candida, influenza, CMV, HSV, VZV)

All low for both CD4 ⁺ and CD8 ⁺

% of donors

Anti TSH receptor ab

+

Anti TPO ab

+

Absolute lymphocyte number

1.7–6.9

0.94

× 10⁹ cells/L

CD3⁺cells

T cells

0.9–4.5

0.60

×  10⁹ cells/L

CD3⁺CD4⁺

0.62–0.86

0.39

× 10⁹ cells/L

CD3⁺CD4⁺CCR7⁺45RA⁺

Naïve CD4⁺T cells

0.26–0.38

0.05

× 10⁹ cells/L

CD3⁺CD4⁺CCR7⁺45RA⁺CD31⁺

CD4⁺ Recent thymic emigrants

0.12–0.24

0.03

× 10⁹ cells/L

CD3⁺CD4⁺CCR7⁺45RA⁻

Central memory CD4⁺ T cells

0.20–0.34

0.13

×  10⁹ cells/L

CD3⁺CD4⁺CCR7⁺45RA⁻CD38⁺HLA-DR⁺

Activated central memory CD4⁺ T cells

0–1

4

×  10⁹ cells/L

CD3⁺CD4⁺CCR7⁻45RA⁻CD38⁺HLA-DR⁺

Activated effector memory CD4⁺ T cells

0–0.01

0.05

×  10⁹ cells/L

CD3⁺CD4⁺CCR7⁺45RA⁻CXCR3⁻CCR6⁺

TH17 cells

0.06–0.10

0.02

× 10⁹ cells/L

CD3⁺CD4⁺CCR4⁺CD25hiCD127low45RO⁻

Naïve Treg

0.02–0.02

< 0.01

×  10⁹ cells/L

CD3⁺CD8⁺

0.25–0.49

0.18

×  10⁹ cells/L

CD3⁺CD8⁺CCR7⁺45RA⁺

Naïve CD8+ T cells

0.07–0.13

< 0.01

× 10⁹ cells/L

CD3⁺CD8⁺CCR7⁺45RA⁻

Central memory CD8+ T cells

0.03–0.05

< 0.01

×  10⁹ cells/L

CD3⁺CD8⁺CCR7⁻45RA⁻CD38⁺HLADR⁺

Activated effector memory CD8⁺ T cells

0–0.01

0.05

× 10⁹ cells/L