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Table 3 Comparison of biochemical and clinical parameters between survivor and non-survivor with sepsis-associated liver dysfunction initially infected by bacteria enrolled in study

From: Continuous hemofiltration improves the prognosis of bacterial sepsis complicated by liver dysfunction in children

Variables Survivors (n = 14) Non-survivors (n = 13) P
Cases with CRRT, n (%) 11 (78.6%) 5 (38.5%) 0.034*
Age, month, median (range) 30 (2–132) 12 (2–192) 0.704
Male, n (%) 5 (35.7%) 8 (61.5%) 0.180
Stay in PICU, day, median (range) 9.5 (4–36) 10 (4–28) 1.000
Body temperature, oC 39 (38–40) 38.8 (36–41) 0.678
Hepatomegaly, n (%) 10 (71.4%) 6 (46.2%) 0.182
Hypoproteinemia, n (%) 9 (64.3%) 13 (100%) 0.083
Pediatric Risk of Mortality III
(PRISM III), median (range)
12.55 (10–17) 14.6 (10–20) 0.252
Co-organ dysfunction
 ARDS, n (%) 9 (64.3%) 4 (30.8%) 0.082
 Kidney injury, n (%) 5 (35.7%) 6 (46.2%) 0.581
 Encephalopathy, n (%) 4 (28.6%) 6 (46.2%) 0.585
 Shock, n (%) 5 (35.7%) 8 (61.5%) 0.180
Infection origin
 Respiratory system, n (%) 8 (57.1%) 3 (23.1%) 0.072
 Digestive system, n (%) 3 (21.4%) 4 (30.8%) 0.580
 Urinary system, n (%) 2 (14.3%) 1 (7.7%) 0.586
 Central nervous system, n (%) 1 (7.1%) 5 (38.5%) 0.050
Pathogens
Escherichia coli, n 5 (35.7%) 5 (38.5%) 0.883
Pseudomonas aeruginosa, n 4 (28.6%) 2 (15.4%) 0.406
Klebsiellapneumoniae, n 1 (7.1%) 0 (0%) 1.000
Streptococcus pneumoniae, n 4 (28.6%) 3 (23.1%) 0.744
Staphylococcus aureus, n 0 (0%) 3 (23.1%) 0.172
Infection markers
 WBC 11.10 ± 8.48 12.96 ± 6.43 0.528
 PCT 5.71 ± 3.64 6.13 ± 4.96 0.805
 CRP 90.07 ± 44.65 106.92 ± 61.66 0.421
Liver function
 ALT 484.21 ± 128.89 643.94 ± 303.62 0.083
 AST 1059.50 ± 848.05 954.94 ± 651.32 0.724
 γ-GT 143.57 ± 69.92 205.46 ± 144.19 0.163
 TBIL 134.55 ± 127.51 232.99 ± 88.49 0.029*
 DBIL 108.89 ± 88.00 169.99 ± 79.64 0.071
 TBA 92.22 ± 21.47 111.93 ± 31.51 0.067
 ALP 166.43 ± 33.24 172.23 ± 32.84 0.653
 PT 20.56 ± 6.47 31.62 ± 26.07 0.136
 APTT 58.83 ± 23.16 66.46 ± 33.73 0.497
 INR 1.55 ± 0.37 2.41 ± 1.94 0.117
 Fib 1.51 ± 0.73 1.91 ± 0.76 0.171
 Lac 4.20 ± 3.45 5.50 ± 3.99 0.410
 Ammonia 139.07 ± 62.24 182.06 ± 75.11 0.122
 TNF-α 96.89 ± 30.65 117.89 ± 37.66 0.123
 IL-6 75.78 ± 21.75 92.27 ± 27.70 0.096
  1. ALT alanine transaminase, U/L, AST aspartate aminotransferase, U/L, γ-GT γ-glutamyltransferase, U/L, TBIL total bilirubin, μmol/L, DBIL direct bilirubin, μmol/L, TBA total bile acid, μmol/L, ALP alkaline phosphatase, U/L, PT prothrombin time, s, APTT activated partial thromboplastin time, s, INR international normalized ratio, Fib ferritin, g/L, Lac lactate, mmol/L; Ammonia, μmol/L, TNF-α tumor necrosis factor α, pg/mL, IL-6 interleukin 6, pg/mL
  2. * indicates P < 0.05 compared with survivors