Table 3 Comparison of biochemical and clinical parameters between survivor and non-survivor with sepsis-associated liver dysfunction initially infected by bacteria enrolled in study
Variables | Survivors (n = 14) | Non-survivors (n = 13) | P |
|---|---|---|---|
Cases with CRRT, n (%) | 11 (78.6%) | 5 (38.5%) | 0.034* |
Age, month, median (range) | 30 (2–132) | 12 (2–192) | 0.704 |
Male, n (%) | 5 (35.7%) | 8 (61.5%) | 0.180 |
Stay in PICU, day, median (range) | 9.5 (4–36) | 10 (4–28) | 1.000 |
Body temperature, oC | 39 (38–40) | 38.8 (36–41) | 0.678 |
Hepatomegaly, n (%) | 10 (71.4%) | 6 (46.2%) | 0.182 |
Hypoproteinemia, n (%) | 9 (64.3%) | 13 (100%) | 0.083 |
Pediatric Risk of Mortality III (PRISM III), median (range) | 12.55 (10–17) | 14.6 (10–20) | 0.252 |
Co-organ dysfunction | |||
ARDS, n (%) | 9 (64.3%) | 4 (30.8%) | 0.082 |
Kidney injury, n (%) | 5 (35.7%) | 6 (46.2%) | 0.581 |
Encephalopathy, n (%) | 4 (28.6%) | 6 (46.2%) | 0.585 |
Shock, n (%) | 5 (35.7%) | 8 (61.5%) | 0.180 |
Infection origin | |||
Respiratory system, n (%) | 8 (57.1%) | 3 (23.1%) | 0.072 |
Digestive system, n (%) | 3 (21.4%) | 4 (30.8%) | 0.580 |
Urinary system, n (%) | 2 (14.3%) | 1 (7.7%) | 0.586 |
Central nervous system, n (%) | 1 (7.1%) | 5 (38.5%) | 0.050 |
Pathogens | |||
Escherichia coli, n | 5 (35.7%) | 5 (38.5%) | 0.883 |
Pseudomonas aeruginosa, n | 4 (28.6%) | 2 (15.4%) | 0.406 |
Klebsiellapneumoniae, n | 1 (7.1%) | 0 (0%) | 1.000 |
Streptococcus pneumoniae, n | 4 (28.6%) | 3 (23.1%) | 0.744 |
Staphylococcus aureus, n | 0 (0%) | 3 (23.1%) | 0.172 |
Infection markers | |||
WBC | 11.10 ± 8.48 | 12.96 ± 6.43 | 0.528 |
PCT | 5.71 ± 3.64 | 6.13 ± 4.96 | 0.805 |
CRP | 90.07 ± 44.65 | 106.92 ± 61.66 | 0.421 |
Liver function | |||
ALT | 484.21 ± 128.89 | 643.94 ± 303.62 | 0.083 |
AST | 1059.50 ± 848.05 | 954.94 ± 651.32 | 0.724 |
γ-GT | 143.57 ± 69.92 | 205.46 ± 144.19 | 0.163 |
TBIL | 134.55 ± 127.51 | 232.99 ± 88.49 | 0.029* |
DBIL | 108.89 ± 88.00 | 169.99 ± 79.64 | 0.071 |
TBA | 92.22 ± 21.47 | 111.93 ± 31.51 | 0.067 |
ALP | 166.43 ± 33.24 | 172.23 ± 32.84 | 0.653 |
PT | 20.56 ± 6.47 | 31.62 ± 26.07 | 0.136 |
APTT | 58.83 ± 23.16 | 66.46 ± 33.73 | 0.497 |
INR | 1.55 ± 0.37 | 2.41 ± 1.94 | 0.117 |
Fib | 1.51 ± 0.73 | 1.91 ± 0.76 | 0.171 |
Lac | 4.20 ± 3.45 | 5.50 ± 3.99 | 0.410 |
Ammonia | 139.07 ± 62.24 | 182.06 ± 75.11 | 0.122 |
TNF-α | 96.89 ± 30.65 | 117.89 ± 37.66 | 0.123 |
IL-6 | 75.78 ± 21.75 | 92.27 ± 27.70 | 0.096 |