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Table 3 Operational definitions of Overall Neurodevelopmental Outcome Groups

From: Twin-to-twin transfusion syndrome neurodevelopmental follow-up study (neurodevelopmental outcomes for children whose twin-to-twin transfusion syndrome was treated with placental laser photocoagulation)

Group 1: Unimpaired Group 2: Mild neurological and/or developmental impairment Group 3: Severe neurological and/or developmental impairment
NO neurological findings on history / examination, AND no functional impairment ANY neurological findings on history/examination which are objectively mild or moderate AND which DO NOT result in severe functional impairment
Examples: Strabismus (squint), Mild talipes (club foot), Mild cerebral palsy (GMFCS I-II)
ANY neurological findings on history/examination which are objectively moderate or severe AND which result in severe functional impairment
Examples: Moderate-Severe cerebral palsy (GMFCS 3–5), Severe visual impairment
NO neurodevelopmental delay or disability in any domain (either on clinical assessment or according to standardised measures) AND no functional impairment ANY neurodevelopmental delay or disability (in one or more domain/s, either on clinical assessment or according to standardised measures), which is objectively mild or moderate, AND which DOES NOT result in severe functional impairment
Examples: Mild intellectual disability (IQ 50-70), Mild Autism Spectrum Disorder, Mild Isolated Speech Delay
ANY neurodevelopmental delay or disability (in one or more domain/s, (either on clinical assessment or according to standardised measures), which is objectively moderate or severe, AND which results in severe functional impairment
Examples: Moderate or Profound intellectual disability (IQ 35–49, or < 30), Moderate or severe Autism Spectrum disorder