Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial)

Table 1 Meta-analysis of COXi versus placebo in preterm neonates with PDA

Outcome	Studies	Participants	Risk Ratio	95%-CI
Mortality	31	3534	0.98	0.84–1.13
BPD (total)	23	3531	1.07	0.98–1.16
BPD (oxygen need at PNA 28 days)	16	1395	1.07	0.94–1.22
BPD (oxygen need at PMA 36 weeks)	8	2136	1.06	0.95–1.20
NEC	23	3285	1.05	0.83–1.32
Death or BPD at PMA 36 weeks	7	2096	1.05	0.97–1.14
IVH	20	3150	0.98	0.88–1.10
Failure of ductal closure	23	1619	0.44	0.38–0.50

CI, Confidence interval; BPD, Bronchopulmonary dysplasia; PNA, Postnatal age; PMA, Postmenstrual age; NEC, Necrotising enterocolitis (any grade); IVH, Intraventricular haemorrhage (any grade)

ISSN: 1471-2431