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Table 1 Meta-analysis of COXi versus placebo in preterm neonates with PDA

From: Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial)

Outcome Studies Participants Risk Ratio 95%-CI
Mortality 31 3534 0.98 0.84–1.13
BPD (total) 23 3531 1.07 0.98–1.16
 BPD (oxygen need at PNA 28 days) 16 1395 1.07 0.94–1.22
 BPD (oxygen need at PMA 36 weeks) 8 2136 1.06 0.95–1.20
NEC 23 3285 1.05 0.83–1.32
Death or BPD at PMA 36 weeks 7 2096 1.05 0.97–1.14
IVH 20 3150 0.98 0.88–1.10
Failure of ductal closure 23 1619 0.44 0.38–0.50
  1. CI, Confidence interval; BPD, Bronchopulmonary dysplasia; PNA, Postnatal age; PMA, Postmenstrual age; NEC, Necrotising enterocolitis (any grade); IVH, Intraventricular haemorrhage (any grade)