Enrolment | Allocation | Follow up | ||||
---|---|---|---|---|---|---|
TIMEPOINT | -t = 2 wks. | 0 | t = 2 wks. | t = 6 wks. | t = 10 wks. | t = 15 wks./study end |
ENROLMENT | ||||||
Eligibility screen | X | |||||
Informed consent | X | |||||
Baseline measurements | X | |||||
Allocation | X | |||||
INTERVENTIONS: | ||||||
Arm 1: All PMC drugs given at discharge without monthly SMS reminder | X | X | X | |||
Arm2: all PMC drugs given at discharge with monthly SMS reminder | X | X | X | |||
Arm 3: All PMC drugs given at discharge with HAS reminder. | X | X | X | |||
Arm 4: PMC drugs collected monthly at the OPD with SMS reminder. | X | X | X | |||
Arm 5: PMC drugs collected monthly at the OPD without SMS reminder | X | X | X | |||
ASSESSMENTS: | ||||||
Physical examination | X | X | ||||
Blood samples | X | X | ||||
Adverse event assessment | X | X | X | X | X | X |
OUTCOMES | ||||||
Adherence | X | |||||
Clinical safety | X | X | X | X | ||
Cost-effectiveness | X | |||||
Acceptability and feasibility | X |