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Table 6 Predictive characteristics of biomarkers for severe AKI

From: Serum and urine FGF23 and IGFBP-7 for the prediction of acute kidney injury in critically ill children

Variable AUC 95% CI P Optimal cut-off value Sensitivity (%) Specificity (%)
PRISM III score 0.92 0.84–0.99 < 0.001 7.5 90.9 77.4
sCysC, mg/L 0.89 0.82–0.97 < 0.001 0.81 90.9 78.2
uCysC, ng/mg uCr 0.88 0.76–0.99 < 0.001 1145.0 81.8 86.5
uIGFBP-7, ng/mg uCr 0.79 0.66–0.92 0.001 563.4 72.7 79.0
uIGFBP-7, combined with sCysC 0.89 0.79–0.99 < 0.001    
uIGFBP-7, combined with uCysC 0.88 0.79–0.98 < 0.001    
uIGFBP-7, combined with sCysC and uCysC 0.90 0.81–1.00 < 0.001    
  1. Severe AKI was defined as AKI network stages 2 and 3
  2. AKI acute kidney injury, AUC the area under the ROC curve, CI confidence interval, PRISM III pediatric risk of mortality III