Serum and urine FGF23 and IGFBP-7 for the prediction of acute kidney injury in critically ill children

BMC Pediatrics

Table 5 Association of variables with severe AKI

Variable	OR	95% CI	P	AOR	95% CI	P
Age, months	1.01	1.00–1.03	0.026	1.01^d	0.99–1.02	0.567
Body weight, kg	1.09	1.03–1.16	0.003	1.03^d	0.96–1.12	0.428
Gender	0.74	0.21–2.65	0.642
PRISM III score	1.36	1.18–1.55	< 0.001	1.32^e	1.15–1.53	< 0.001
MV	16.08	2.00–129.36	0.009	5.03^f	0.50–50.56	0.170
Duration of MV, hours	1.00	1.00–1.00	0.494
Sepsis	3.23	0.87–12.05	0.081
eGFR, mL/min	0.98	0.96–1.01	0.138
sFGF23, pg/mL	1.00	0.99–1.01	0.730
sIGFBP-7, ng/mL	1.01	0.99–1.02	0.096
sCysC, mg/L	6.67	1.84–24.18	0.004	5.28^{f, g}	1.64–16.99	0.005
uFGF23, pg/mg uCr	1.15^a	0.47–2.82	0.761
uIGFBP-7, ng/mg uCr	4.37^b	1.82–10.49	0.001	2.94^{b, f, g}	1.08–8.01	0.035
uCysC, ng/mg uCr	1.21^c	1.10–1.34	< 0.001	1.13^{c, f, g}	1.02–1.25	0.022

AKI, acute kidney injury; AOR, Adjusted OR; CI, confidence interval; eGFR, estimated glomerular filtration rate; MV, mechanical ventilation; OR, odds ratio; PRISM III, pediatric risk of mortality III
Severe AKI was defined as AKI network stages 2 and 3
^aOdds ratio represents the increase in risk per 1000 pg/mg increase in uFGF23/uCr. ^bOdds ratio represents the increase in risk per 1000 ng/mg increase in uIGFBP-7/uCr. ^cOdds ratio represents the increase in risk per 1000 ng/mg increase in uCysC/uCr
^dAfter adjustment for PRISM III score. ^eAfter adjustment for age and body weight. ^fAfter adjustment for body weight and PRISM III score. ^gP < 0.05, after adjustment for body weight, sepsis, and PRISM III score

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