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Table 5 Association of variables with severe AKI

From: Serum and urine FGF23 and IGFBP-7 for the prediction of acute kidney injury in critically ill children

Variable OR 95% CI P AOR 95% CI P
Age, months 1.01 1.00–1.03 0.026 1.01d 0.99–1.02 0.567
Body weight, kg 1.09 1.03–1.16 0.003 1.03d 0.96–1.12 0.428
Gender 0.74 0.21–2.65 0.642    
PRISM III score 1.36 1.18–1.55 < 0.001 1.32e 1.15–1.53 < 0.001
MV 16.08 2.00–129.36 0.009 5.03f 0.50–50.56 0.170
Duration of MV, hours 1.00 1.00–1.00 0.494    
Sepsis 3.23 0.87–12.05 0.081    
eGFR, mL/min 0.98 0.96–1.01 0.138    
sFGF23, pg/mL 1.00 0.99–1.01 0.730    
sIGFBP-7, ng/mL 1.01 0.99–1.02 0.096    
sCysC, mg/L 6.67 1.84–24.18 0.004 5.28f, g 1.64–16.99 0.005
uFGF23, pg/mg uCr 1.15a 0.47–2.82 0.761    
uIGFBP-7, ng/mg uCr 4.37b 1.82–10.49 0.001 2.94b, f, g 1.08–8.01 0.035
uCysC, ng/mg uCr 1.21c 1.10–1.34 < 0.001 1.13c, f, g 1.02–1.25 0.022
  1. AKI, acute kidney injury; AOR, Adjusted OR; CI, confidence interval; eGFR, estimated glomerular filtration rate; MV, mechanical ventilation; OR, odds ratio; PRISM III, pediatric risk of mortality III
  2. Severe AKI was defined as AKI network stages 2 and 3
  3. aOdds ratio represents the increase in risk per 1000 pg/mg increase in uFGF23/uCr. bOdds ratio represents the increase in risk per 1000 ng/mg increase in uIGFBP-7/uCr. cOdds ratio represents the increase in risk per 1000 ng/mg increase in uCysC/uCr
  4. dAfter adjustment for PRISM III score. eAfter adjustment for age and body weight. fAfter adjustment for body weight and PRISM III score. gP < 0.05, after adjustment for body weight, sepsis, and PRISM III score