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Table 1 Demographic and clinical characteristics grouped according to AKI status

From: Serum and urine FGF23 and IGFBP-7 for the prediction of acute kidney injury in critically ill children

Variable Non-AKI Mild AKI Severe AKI P
(n = 123) (n = 10) (n = 11)
Age, months 12 [4–48] 30.5 [11.25–98] 59 [4–98] 0.049&
Body weight, kg 10 [6.5–14] 14 [8.75–26.25] 20 [6.5–30]* 0.024&
Male, n 70 (56.9) 5 (50.0) 7 (63.6) 0.819
PRISM III score 3 [0.25–6.75] 7.5 [4.25–10.5]* 17 [8–20]*# < 0.001
Arterial pHa 7.409 [7.363–7.468] 7.461 [7.392–7.481] 7.400 [7.203–7.497] 0.297
Blood bicarbonatea, mmol/L 20.0 [17.6–22.2] 17.1 [15.5–20.0]* 17.1 [8.1–19.6]* 0.020φ
Serum albumina, g/L 41.7 [38.5–44.4] 40.2 [34.9–46.9] 35.3 [26.7–43.8]* 0.026φ
Serum creatininea, μmol/L 24.6 [19.5–31.8] 44.3 [26.9–72.1]* 86.4 [77.3–140.0]*# < 0.001φ
Blood urea nitrogena, μmol/L 3.30 [2.54–4.40] 6.34 [3.41–8.53]* 7.00 [5.84–13.44]* < 0.001φ
Serum sodiuma, μmol/L 134.6 [132.3–136.6] 135.8 [133.2–140.3] 132.8 [130.3–133.7]*# 0.008ζ
Serum potassiuma, μmol/L 4.02 [3.57–4.56] 4.31 [3.77–4.47] 4.32 [3.83–5.60] 0.157
MODSb, n 3 (2.4) 2 (20.0)* 6 (54.5)* < 0.001φ
Shock/DICb, n 11 (8.9) 2 (20.0) 5 (45.5)* < 0.001ζ
MVc, n 45 (36.6) 6 (60.0) 10 (90.9)* 0.001ζ
Duration of MVc, hours 0 [0–44] 35 [0–123.5] 115 [12–134]* 0.001ζ
Prolonged MV (> 48 h)c, n 26 (21.1) 4 (40.0) 8 (72.7)* 0.002φ
Antibioticsc, n 116 (94.3) 10 (100) 11 (100) 0.322
Inotropec, n 23 (18.7) 1 (10.0) 8 (72.7)*# 0.001φ
Furosemidec, n 31 (25.2) 3 (30.0) 11 (100)*# 0.032φ
Steroidsc, n 45 (36.6) 3 (30.0) 5 (45.5) 0.757
PICU LOS, hours 66 [36–141] 77.5 [38.25–256] 152 [118–181]* 0.032ζ
Death, n 5 (4.1) 1 (10.0) 2 (18.2) 0.093
  1. Values are median [interquartile range]. Numbers in parentheses denote percentages
  2. AKI network stage 1 was defined as mild AKI, and AKIN stages 2 and 3 were defined as severe AKI. AKI acute kidney injury, DIC disseminated intravascular coagulation, LOS length of stay, MODS multiple organ dysfunction syndrome, MV mechanical ventilation, PICU pediatric intensive care unit, PRISM III pediatric risk of mortality III
  3. aThe first available laboratory results during the first 24 h after PICU admission. bDeveloped during PICU stay. cAdministration during PICU stay
  4. *P < 0.05, compared with non-AKI; #P < 0.05, compared with mild AKI. &P > 0.05, after adjustment for PRISM III score. ζP > 0.05, φP < 0.05, after adjustment for body weight and PRISM III score