Table 3 Cholestasis outcomes by drug treatment
From: Ursodeoxycholic acid versus phenobarbital for cholestasis in the Neonatal Intensive Care Unit
Phenobarbital | Ursodiol | p-value | |
|---|---|---|---|
Univariate analysis (first course only) | |||
Change in direct Bilirubin | 0.03 | ||
mg/dl | + 0.76 | −1.89 | |
umol/L | + 13.0 | −32.3 | |
Direct Bili at end of drug therapy | 0.02 | ||
mg/dl | 7.84 | 4.98 | |
umol/L | 134.1 | 85.2 | |
Adjusted for direct Bilirubin at start of drug therapy | |||
Change in direct Bilirubin | |||
First course | 0.01 | ||
mg/dl | + 0.81 | −1.95 | |
umol/L | + 13.85 | - 33.35 | |
All Courses | <0.01 | ||
mg/dl | + 0.66 | −3.63 | |
umol/L | + 11.29 | −62.08 | |
Direct Bili at end of drug therapy (mg/dl) | |||
First course | 0.01 | ||
mg/dl | 7.79 | 5.03 | |
umol/L | 133.24 | 86.03 | |
All Courses | <0.01 | ||
mg/dl | 8.27 | 3.98 | |
umol/L | 141.45 | 68.07 | |
Adjusted for direct Bilirubin at start of drug therapy, IUGR and limited lipids | |||
Change in direct Bilirubin | |||
First course | 0.03 | ||
mg/dl | + 0.27 | −2.16 | |
umol/L | + 4.62 | −36.94 | |
All Courses≠ | |||
< 0.01 | |||
mg/dl | + 0.28 | −3.96 | |
umol/L | + 4.79 | −67.73 | |
Direct Bili at end of drug therapy (mg/dl) | |||
First Course | 0.03 | ||
mg/dl | 7.25 | 4.83 | |
umol/L | 124.0 | 82.61 | |
All Coursesa | < 0.01 | ||
mg/dl | 7.89 | 3.65 | |
umol/L | 134.95 | 62.43 | |