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Table 4 Clinical characteristics and comparison between Lyme neuroborreliosis patients with or without erythema migrans

From: Occurrence of erythema migrans in children with Lyme neuroborreliosis and the association with clinical characteristics and outcome – a prospective cohort study

On admission and at follow-up Patients with LNB and EM (n = 37) Patients with LNB without EM (n = 66) p-value
Gender
 Female, n (%) 14 (38) 31 (47)  
 Male, n (%) 23 (62) 35 (53) 0.37
Age, median (range) 7 (2–15) 7 (2–15) 0.53
Observed tick bite, n (%) 25 (68) 34(52) 0.11
Clinical characteristics
 Facial nerve palsy, n (%) 26 (70) 45 (68) 0.83
 Headache, n (%) 23 (62) 50 (76) 0.15
 Fatigue, n (%) 34 (92) 51 (77) 0.10
 Fever, n (%) 21 (57) 28 (42) 0.16
 Neck pain, n (%) 17 (46) 37 (56) 0.32
 Neck stiffness, n (%) 13 (35) 21 (32) 0.73
 Loss of appetite, n (%) 22 (60) 40 (61) 0.91
 Nausea, n (%) 13 (35) 23 (35) 0.98
 Vertigo, n (%) 7 (19) 10 (15) 0.62
Duration of neurological symptoms
 1–2 days, n (%) 5 (14) 6 (9) 0.52
 3–6 days, n (%) 17 (46) 25 (38) 0.42
 1–2 weeks, n (%) 7 (19) 19 (29) 0.27
 2–4 weeks, n (%) 5 (14) 10 (15) 1.00
 1–2 months, n (%) 1 (3) 0 (0) 0.36
  > 2 months 1 (3) 2 (3) 1.00
 Not specified, n (%) 1 (3) 4 (6) 0.65
Clinical outcome
 Total recovery within 2 months, n (%) 31 (84) 56 (85) 0.43
Major persistent symptom
 Facial nerve palsy, n (%) 2 (5) 7 (11) 0.48
 Headache, n (%) 1 (3) 2 (3) 1.00
 Fatigue, n (%) 1 (3) 0 (0) 0.36
  1. EM erythema migrans, LNB Lyme neuroborreliosis; patient are classified according to European guidelines [13]