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Table 2 Immunological features of EIgM and NIgM patients

From: Elevated IgM levels as a marker for a unique phenotype in patients with Ataxia telangiectasia

Parametera EIgM
N = 15
NIgM
N = 31
p
WBC (K/mL) 8.8 ± 1.6 8 ± 2.9 p = 0.16
ANC (K/ml) 5.6 ± 1.3 5.2 ± 2.5 p = 0.3
ALC (K/ml) 1.7 ± 0.5 1.9 ± 0.8 p = 0.25
CD3 + (K/ml) 1042 ± 526 959 ± 511 p = 0.33
CD4 + (K/ml) 466 ± 236 839 ± 1797 p = 0.25
CD8 + (K/ml) 597 ± 433 443 ± 247 p = 0.09
CD20 + (K/ml) 145 ± 67 167 ± 185 p = 0.36
CD56+ (K/ml) 26 ± 10 23 ± 10.7 p = 0.24
Patients treated with IVIG 10/13(77) 14/27(52) p = 0.13
Age at IVIG initiation (years) 9.4 ± 5.7 6.6 ± 3.7 p = 0.09
Average IgA (mg/dL) 82 ± 97 59.5 ± 81 p = 0.22
C3(mg/dL) 146 ± 30.4 144.1 ± 11.3 p = 0.46
C4(mg/dL) 27 ± 8 37.4 ± 1.8 p = 0.06
KREC-CJ 732 ± 390 2568 ± 3115 p = 0.033
KREC-SJ 22 ± 17 112 ± 199 p = 0.08
TREC 13.9 ± 8.2 64.2 ± 93.5 p = 0.046
Normal lymphocyte proliferation 6/9(67) 19/23(83) p = 0.33
  1. WBC white blood cells, ANC Absolute neutrophil count, ALC absolute lymphocyte count, IVIg Intravenous immune globulin, C Complement, NK Natural Killer cell, TREC T cell receptor excision circle, KREC kappa-deleting recombination excision circles (CJ ψJα coding joint, SJ ψJα signal joint)
  2. aContinuous variables are presented as mean ± SD. Categorical variables are presented as N (%)