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Table 2 Immunological features of EIgM and NIgM patients

From: Elevated IgM levels as a marker for a unique phenotype in patients with Ataxia telangiectasia

Parametera

EIgM

N = 15

NIgM

N = 31

p

WBC (K/mL)

8.8 ± 1.6

8 ± 2.9

p = 0.16

ANC (K/ml)

5.6 ± 1.3

5.2 ± 2.5

p = 0.3

ALC (K/ml)

1.7 ± 0.5

1.9 ± 0.8

p = 0.25

CD3 + (K/ml)

1042 ± 526

959 ± 511

p = 0.33

CD4 + (K/ml)

466 ± 236

839 ± 1797

p = 0.25

CD8 + (K/ml)

597 ± 433

443 ± 247

p = 0.09

CD20 + (K/ml)

145 ± 67

167 ± 185

p = 0.36

CD56+ (K/ml)

26 ± 10

23 ± 10.7

p = 0.24

Patients treated with IVIG

10/13(77)

14/27(52)

p = 0.13

Age at IVIG initiation (years)

9.4 ± 5.7

6.6 ± 3.7

p = 0.09

Average IgA (mg/dL)

82 ± 97

59.5 ± 81

p = 0.22

C3(mg/dL)

146 ± 30.4

144.1 ± 11.3

p = 0.46

C4(mg/dL)

27 ± 8

37.4 ± 1.8

p = 0.06

KREC-CJ

732 ± 390

2568 ± 3115

p = 0.033

KREC-SJ

22 ± 17

112 ± 199

p = 0.08

TREC

13.9 ± 8.2

64.2 ± 93.5

p = 0.046

Normal lymphocyte proliferation

6/9(67)

19/23(83)

p = 0.33

  1. WBC white blood cells, ANC Absolute neutrophil count, ALC absolute lymphocyte count, IVIg Intravenous immune globulin, C Complement, NK Natural Killer cell, TREC T cell receptor excision circle, KREC kappa-deleting recombination excision circles (CJ ψJα coding joint, SJ ψJα signal joint)
  2. aContinuous variables are presented as mean ± SD. Categorical variables are presented as N (%)