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Table 2 Maternal thyroid disorder and risk of cerebral palsy

From: Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child: a population-based cohort study

Danish register-based study population

Maternal thyroid disordera

All CP (No = 2798)

Unilateral Spastic CP (No = 912)

Bilateral Spastic CP (No = 1490)

 

No

No

ORb (95% CI)

ORc (95% CI)

No

ORb (95% CI)

ORc (95% CI)

No

ORb (95% CI)

ORc (95% CI)

No thyroid disorder

1,246,454

2748

1 (ref.)

1 (ref.)

894

1 (ref.)

1 (ref.)

1465

1 (ref.)

1 (ref.)

Thyroid disorderd

23,625

50

0.96 (0.73–1.27)

0.99 (0.74–1.31)

18

1.06 (0.67–1.69)

0.93 (0.58–1.48)

25

0.90 (0.61–1.34)

1.03 (0.69–1.53)

 Hypothyroidism

12,929

26

0.91 (0.62–1.34)

0.95 (0.64–1.39)

9

0.97 (0.50–1.87)

0.83 (0.43–1.61)

13

0.86 (0.50–1.48)

1.01 (0.58–1.74)

 Hyperthyroidism

9943

24

1.10 (0.73–1.64)

1.11 (0.94–1.66)

9

1.26 (0.65–2.43)

1.13 (0.59–2.18)

12

1.03 (0.58–1.81)

1.13 (0.64–1.99)

Identification of thyroid disorder

No

1,246,454

2748

1 (ref.)

1 (ref.)

894

1 (ref.)

1 (ref.)

1465

1 (ref.)

1 (ref.)

Before pregnancy

9622

20

0.94 (0.61–1.46)

0.97 (0.62–1.50)

7

1.01 (0.48–2.13)

0.86 (0.41–1.81)

11

0.97 (0.54–1.76)

1.13 (0.62–2.04)

In pregnancy

1551

7

2.05 (0.98–4.32)

2.00 (0.95–4.21)

4

3.60 (1.35–9.63)

3.14 (1.17–8.42)

<4f

NE

NE

≀ 5 years after pregnancy

12,452

23

0.84 (0.56–1.26)

0.87 (0.58–1.31)

7

0.78 (0.37–1.65)

0.70 (0.33–1.48)

12

0.82 (0.46–1.45)

0.94 (0.53–1.66)

MOBAND study population

Maternal thyroid disorder in pregnancy

All CP (No = 402)

 

No

No

ORb (95% CI)

ORc (95% CI)

ORe (95% CI)

 

No thyroid disorder

189,876

394

1 (ref.)

1 (Ref.)

1 (ref.)

 

Thyroid disorder

3042

8

1.27 (0.63–2.55)

1.18 (0.58–2.39)

1.17 (0.58–2.38)

 

 No medicationg

534

3

2.71 (0.87–8.46)

2.54 (0.81–7.94)

2.54 (0.81–7.93)

 

 Use of medicationg

2229

4

0.86 (0.32–2.30)

0.82 (0.30–2.19)

0.82 (0.30–2.19)

 
  1. Multiple logistic regressions were used to calculate odds ratios (ORs) with 95% confidence intervals (95% CIs) in data with multiple imputation of missing values
  2. Abbreviations: CP cerebral palsy, No number in complete case data, NE no estimate, MOBAND MOthers and BAbies in Norway and Denmark
  3. aMaternal thyroid disorder identified before pregnancy until 5 years subsequent to pregnancy
  4. bUnadjusted
  5. cAdjusted for birth year, maternal age, maternal diabetes, and maternal socioeconomic status
  6. dUnclassifiable thyroid disorder is included in the overall measure of thyroid disorder in addition to hypothyroidism and hyperthyroidism
  7. eAdjusted for birth year, maternal age, maternal diabetes, maternal socioeconomic status, and smoking and alcohol consumption in pregnancy
  8. fThe governmental organization Statistics Denmark responsible for the register-based data, do not allow data extraction of figures below four
  9. gInformation on maternal use of thyroid medication was available for 2763 children exposed to maternal thyroid disorder in the MOBAND study, missing information has been imputed