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Table 7 Differences in the evidence certainty across evidence sources in the depression treatment NMA

From: Network meta-analysis: users’ guide for pediatricians

Comparison

Direct evidence

Direct evidence certainty in estimates

Indirect evidence

Indirect evidence certainty in estimatesf

Network

Network certainty in estimates

Fluoxetine vs. Placebo

−0.26 (−0.50, −0.03)

OOO VERY LOWa,b,c

−1.41 (−2.35, − 0.47)

O MODERATEd

− 0.51 (− 0.99, − 0.03)

OOO VERY LOWb,e

  1. arated down for RoB
  2. brated down for imprecision (upper CI close to the null)
  3. crated down for heterogeneity (I2 = 67.4%)
  4. dloops informed the indirect evidence were of low ROB, imprecise (Duloxetine-placebo [SMD = − 0.11 95%CrI -0.3, 0.08; I2 = 17%], Duloxetine- Fluoxetine [SMD = − 0.09 95%CrI -0.26, 0.08; I2 = 0%], no intransitivity
  5. erated down for incoherence (τ2 = 0.33, P value = 0.02)
  6. Effect estimates are SMD (95th CI) [41]
  7. fAssessed from first order loop Duloxetine-placebo (n = 552), Duloxetine- Fluoxetine (n = 557), included 7–17 years old children, treated for 10 weeks