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Table 2 GRADE evidence profile showing differences in the evidence certainty among two direct evidence comparisons in the depression treatment NMA for depression symptoms

From: Network meta-analysis: users’ guide for pediatricians

Quality assessment

Quality

№ of studies

Risk of bias

Inconsistency

Indirectness

Imprecision

Other considerations

Absolute Effect (95% CI)

 

Fluoxetine vs. placebo

8

Seriousa

Seriousb

Not serious

Seriousc

None

SMD 0.26 SD lower (0.5 lower to 0.03 lower)

⊕OOO VERY LOW

Imipramine vs. placebo

2

Not serious

Not serious

Not serious

Seriousd

None

SMD 0 SD (0.27 lower to 0.26 higher)

⊕⊕⊕O MODERATE

  1. RCT Randomised trials; CI Confidence interval, SMD Standardised mean difference [41]
  2. aSelective outcome reporting, and incomplete outcome data
  3. bModerate heterogeneity I2 = 67.4%
  4. cUpper CI very close to no effect
  5. dSMD includes no effect
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BMC Pediatrics

ISSN: 1471-2431

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