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Table 1 Congenital Rhabdomyosarcoma: review of the literature

From: Congenital Rhabdomyosarcoma: a different clinical presentation in two cases

Patient and disease characteristics

ERMS ptse

(n = 16)

ARMS ptse

(n = 17)

Gender: female/male (sex ratio)

5/11 (0.45)

10/7 (1.4)

Primary site

 PM head & neck

–

1

 Non PM head & neck

6

4

 Orbit

–

–

 GU non bladder-prostate

2

–

 GU bladder-prostate

2

–

 Extremities

1

7

 Other site

5a

4b

 NA

–

1

IRSG

 I

1

–

 II

4

1

 III

11

3

 IV

1

13c

Molecular biology

 Negative

2

5

 NA

12

8

 PAX3-FOXO1 positive

–

3

 PAX7-FOXO1 positive

–

–

 Others

2 [t(2;8)]

1 [N-myc amplification]

Therapy

 NA

–

1

 Surgery only

2

–

 Chemotherapy only

2

9

 Chemotherapy + surgery

9

4

 Chemotherapy + surgery + radiotherapy

3

2

 Chemotherapy + radiotherapy

–

1

Outcome

 Alive [median months from dg (range)]

8 [31.5 (6–240)]

4 [9 (6–240)]

 Dead

2

13d

 NA

6

–

  1. ERMS embryonal rhabdomyosarcoma, ARMS alveolar rhabdomyosarcoma, pts. patients, PM parameningeal, n number, GU genito-urinary, NA not available, IRSG Intergroup Rhabdomyosarcoma Study Group, dg diagnosis
  2. a2-perineal, 2-chest wall, 1-trunk
  3. b2-trunk, 2-chest wall
  4. cFor all patients, cutaneous and subcutaneous tissue was a metastatic site
  5. d7/13 patients had central nervous system disease progression
  6. eData about family history of cancer were not available