Fig. 2From: A novel homozygous mutation in POLR3A gene causing 4H syndrome: a case reporta, b, c, d, e, f Matched TSE T2W axial images (a to c) and IR T1W axial images (d to f) of the brain show diffuse signal alteration in the entire cerebral white matter including the internal and external capsules and the pre-aqueductal region, appearing hyperintense on T2WI and hypointense on matched T1WI. There is diffuse sulcal prominence indicative of cerebral atrophyBack to article page