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Table 4 Associations between DNA methylation status at CpG sites and metabolic profiles adjusted for age, gender, and BMI

From: Association between the DNA methylations of POMC, MC4R, and HNF4A and metabolic profiles in the blood of children aged 7–9 years

 

TC

HDL–c

β (SE)

p

β (SE)

p

POMC

POMC–CpG1

−0.15 (0.24)*

0.52

−0.20 (0.11)*

0.08

POMC–CpG2

−0.32 (0.25)*

0.20

−0.23 (0.12)*,a

0.048a

POMC–CpG3

− 0.16 (0.24)*

0.50

− 0.18 (0.11)*

0.12

POMC–CpG4

−0.23 (0.26)*

0.39

−0.20 (0.12)*

0.10

HNF4A–P1

HNF4A–CpG4

−2.79 (0.76)*,a

0.001†

−0.67 (0.37)*

0.07

HNF4A–P2

HNF4A–CpG3

5.70 (1.76)*,a

0.002†

1.14 (0.86)

0.19

  1. Results are presented as coefficients (β) and SE after adjusting for age, gender, and BMI
  2. aindicate statistically significant associations. * indicates the hypomethylated
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BMC Pediatrics

ISSN: 1471-2431

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