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Table 3 Adverse event (AE) incidence in randomized studies with racecadotril as compared to various comparators. Data are based on 41 studies from Table 1 that have provided treatment-specific AE data. AE incidence in a large observational study is shown for comparison [27]. For details see section 5

From: Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials

 

Comparator

Racecadotril

 
 

# of patients

# of AE

% of AE

# of patients

# of AE

% of AE

All randomized studies

2253

92

4.1

2373

104

4.4

Blinded placebo-controlled

312

33

10.6

326

34

10.4

Open add-on studies

1480

38

2.6

1575

54

3.4

Blinded active controlled

50

11

22.0

52

6

8.7

Open active controlled

411

10

2.4

420

10

2.4

Observational study

–

–

–

3873

0

0