| Comparator | Racecadotril |  | |||
---|---|---|---|---|---|---|
 | # of patients | # of AE | % of AE | # of patients | # of AE | % of AE |
All randomized studies | 2253 | 92 | 4.1 | 2373 | 104 | 4.4 |
Blinded placebo-controlled | 312 | 33 | 10.6 | 326 | 34 | 10.4 |
Open add-on studies | 1480 | 38 | 2.6 | 1575 | 54 | 3.4 |
Blinded active controlled | 50 | 11 | 22.0 | 52 | 6 | 8.7 |
Open active controlled | 411 | 10 | 2.4 | 420 | 10 | 2.4 |
Observational study | – | – | – | 3873 | 0 | 0 |