Fig. 8

Effect of racecadotril on global parameters of efficacy assessed 72 h after start of treatment. Shown are degree of improvement classified as ‘ineffective’, ‘effective’ and ‘markedly effective’ (upper panel), as ‘not improved’, ‘improved’ and ‘cured’ (middle panel) and as % of patient considered cured at end of third treatment day (lower panel Each data point represents one study; for lower panel data points within a study are connected by a line. Note that comparator treatments included placebo (n = 1, 2 and 2 studies, respectively), various background treatments (n = 22, 9 and 30 studies, respectively) and active comparator treatments (n = 9, 2 and 10 studies, respectively); for details see section 4. Descriptive P-values are based on paired, two-tailed t-tests comparing % values within a category between the two treatments