Table 3 Clinical data of family members with diabetes mellitus or impaired fasting glucose
Patients | Family member | DM/IFG diagnosed age (years) | Treatment | At genetic confirmation of GCK-MODY | |||
|---|---|---|---|---|---|---|---|
Age (years) | BMI (kg/m2) | FPG (mmol/L) | HbA1c (%/ mmol/mol) | ||||
Case 1 | Father | 32 | No | 37 | 20.4 | 6.5 | 7.1/54.1 |
Case 2 | Father | 35 | No | 38 | 19.5 | 7.1 | 6.9/51.9 |
Grandmother | 51 | Glibenclamide | 65 | 22.5 | 6.8 | 7.1/54.1 | |
Case 3 | Mother | – | – | 29 | 20.5 | 6.4 | 6.8/50.8 |
Case 4 | Mother | 42 | No | 46 | 21.5 | 5.8 | 6.3/45.4 |
Case 5 | Mother | 39 | Diet, active exercise | 42 | 21.8 | 6.1 | 6.2/44.3 |
Case 6 | Mother | – | – | 35 | 20.9 | 7.8 | 6.4/46.5 |
Grandfather | 50 | Metformin | 70 | 22.7 | 6.3 | 6.5/47.5 | |
Case 7 | Father | – | – | 37 | 24.1 | 6.2 | 6.4/46.5 |
Case 8 | Mother | – | – | 37 | 25.1 | 7.0 | 6.9/51.9 |
Grandmother | 42 | Metformin for 2 years and wean off at age of 44 years | 64 | 23.6 | 6.3 | 7.4/57.4 | |
Case 9 | Father | 36 | Metformin | 39 | 21.8 | 6.9 | 7.0/53.0 |
Grandfather | 40 | No | 65 | 21.6 | 6.5 | 6.5/47.5 | |