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Table 6 Respiratory Health the past 12 Months for Extremely Preterm Children Born in Norway During 1999 and 2000 at a Gestational Age < 28 Weeks or with a Birth Weight < 1000 Grams Assessed at Five and 11 Years of Age by the International Study of Asthma and Allergy in Childhood Questionnaire

From: Respiratory morbidity through the first decade of life in a national cohort of children born extremely preterm

 

At 5 years of age n = 284

At 11 years of age n = 232

 

Rate (95% CI)

Rate (95% CI)

p-valuesa

Wheezing

26% (21–32%)

16% (11–21%)

< 0.001

Wheeze on exercise

20% (15–25%)

18% (13–23%)

0.200

Dry cough at night

23% (18–28%)

16% (11–21%)

0.028

Ever awakened due to wheezing

15% (11–19%)

7% (4–10%)

0.001

Current asthma (criteria-based)b

26% (21–31%)

16% (11–20%)

< 0.001

Severe asthma (criteria-based)c

13 (9–17%)

8% (4–11%)

0.064

Current use of asthma medication

26% (21–31%)

15% (10–19%)

< 0.001

  1. Figures are the percentage of children with a positive response with the corresponding 95% confidence interval (95% CI)
  2. aMc Nemar’s test. Boldface denotes significant rate differences
  3. bDefined by either (1) a doctor’s diagnosis of asthma and either respiratory symptoms or use of asthma medication in the previous 12 months, or (2) use of asthma medication and symptoms in the past 12 months even if no recall of prior doctor’s diagnosis
  4. cDefined by four or more episodes of wheezing, or sleep disturbances (awakened more than once a week), or problems of speaking due to wheezing reported during the past 12 months (14)