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Table 1 Early Characteristics of Extremely Preterm Children Born in Norway During 1999 and 2000 at a Gestational Age < 28 Weeks or with a Birth Weight < 1000 Grams, According to Whether Response Was Given to the Parental Questionnaire at 11 Years of Age

From: Respiratory morbidity through the first decade of life in a national cohort of children born extremely preterm

 

Parental questionnaire at 11 years of agea

 

Responders

n = 232

Non-responders

n = 140

p-valueb

Gestational age, median (interquartile range)

27 (26–28)

26 (25–27)

0.014

Birth weight, median (interquartile range)

880 (766–994)

847 (715–979)

0.376

Illness severity scorec, median (interquartile range)

1 (0–2)

1 (0.5–1.5)

0.063

Length of initial stay, median (interquartile range)

92 (70–114)

89 (67–111)

0.483

Male sex

115/232 (50%)

85/140 (61%)

0.037

Caesarean section

159/232 (69%)

84/140 (60%)

0.094

Mother higher education

109/227 (48%)

40/120 (33%)

0.009

Premature rupture of membranesd

26/217 (12%)

13/125 (10%)

0.658

Multiple births

56/232 (24%)

27/140 (19%)

0.276

Bronchopulmonary dysplasiae

113/232 (49%)

52/140 (37%)

0.030

Patent ductus arteriosus

93/232 (40%)

50/140 (36%)

0.401

Small for gestational agef

46/232 (20%)

23/140 (16%)

0.414

Sepsis

52/232 (22%)

36/140 (26%)

0.468

Cerebral ultrasound findingsg

 No pathology

152/232 (66%)

94/140 (67%)

0.814

 Minor pathology

61/232 (26%)

33/140 (24%)

 

 Major pathology

19/232 (8%)

13/140 (9%)

 

Prenatal steroids

164/232 (71%)

93/140 (66%)

0.389

Postnatal steroids

82/232 (35%)

47/140 (34%)

0.728

Mother’s age, mean (standard deviation)

30 (5)

29 (6)

0.280

Chorioamnionitis

32/232 (14%)

35/140 (25%)

0.006

Preeclampsia

56/232 (24%)

34/140 (24%)

0.974

Retinopathy of prematurity

60/232 (26%)

52/138 (38%)

0.017

Smoking in pregnancy

46/191 (24%)

47/124 (38%)

0.009

Cerebral palsy, blind or deaf at five years of age

13/232 (6%)

20/140 (14%)

0.004

Home oxygen treatment

22/231 (10%)

9/124 (7%)

0.471

Surfactant

192/232 (83%)

104/140 (74%)

0.050

Lung disease at two years of age

62/223 (28%)

45/131 (34%)

0.195

  1. aFigures are given as n (%), unless otherwise specified. Percentages were calculated from the actual response rates that varied slightly between the items
  2. bMann Whitney’s U test, Student’s T-test, or χ2 test, as appropriate. Boldface denotes significant group differences
  3. cA score based on lowest and highest fractional oxygen (FIO2) requirements and the base deficit during the first 12 hours of life
  4. dDefined as rupture of membranes more than  six days before delivery
  5. eDefined as assisted ventilation or oxygen supplementation at 36 weeks postmenstrual age
  6. fDefined as less than the fifth percentile for GA and gender according to Norwegian growth curves
  7. gMinor pathology defined as periventricular haemorrhage grade 1 to 2, or a maximum of two small cysts, and major pathology defined as periventricular haemorrhage grade 3 to 4 or multi-cystic periventricular leukomalacia
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BMC Pediatrics

ISSN: 1471-2431

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