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Table 4 Measured cytokines in serum and interstitial fluid throughout therapeutic hypothermia

From: Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study

Cytokines Therapeutic Hypothermia, hours after birth
7 h 13 h 25 h 49 h 73 h Significance
IFN-γ (pg/ml) Serum 26 ± 25 5 ± 65 NM NM NM  
IF 24 ± 18 3 ± 25 39 ± 36 47 ± 59 28 ± 25 NS
IL-1α (pg/ml) Serum 119 ± 41 287 ± 501 300 ± 280 246 ± 262 958 ± 945 NS
IF 1840 ± 2034 2387 ± 2719 2652 ± 2682 2562 ± 3006 8845 ± 7055 P < 0.051
IL-1RA (pg/ml) Serum 38,845 ± 29,946 18,663 ± 17,076 8226 ± 9959 7917 ± 10,524 3069 ± 4132 P < 0.052
IF 1966 ± 1219 1141 ± 787 849 ± 1338 751 ± 421 2033 ± 2047 P < 0.053
IL-6 (pg/ml) Serum 6441 ± 6935 3343 ± 4747 9419 ± 4747 4204 ± 11,622 4297 ± 11,622 P < 0.054
IF 1646 ± 2663 742 ± 1098 868 ± 1325 964 ± 232 134 ± 104 NS
IL-8 (pg/ml) Serum 3733 ± 2641 3025 ± 3590 2648 ± 4248 2059 ± 2567 1940 ± 2570 NS
IF 678 ± 904 642 ± 904 1192 ± 2628 669 ± 1022 366 ± 534 NS
IL-10 (pg/ml) Serum 12,519 ± 11,403 5059 ± 9073 557 ± 664 647 ± 1468 327 ± 665 P < 0.055
IF NM NM NM NM NM  
IL-12p40 (pg/ml) Serum 1018 ± 930 1064 ± 1088 1132 ± 1224 836 ± 875 NM NS
IF NM NM NM NM NM  
MCP-1α (pg/ml) Serum 51,752 ± 36,294 52,073 ± 43,265 63,297 ± 49,865 71,682 ± 42,825 54,762 ± 41,092 NS
IF 3369 ± 2900 4367 ± 5604 6260 ± 8353 4381 ± 4062 5955 ± 3863 NS
TGFα (pg/ml) Serum 64 ± 84 74 ± 98 53 ± 59 95 ± 114 73 ± 73 NS
IF NM NM NM NM NM  
TNFα (pg/ml) Serum 503 ± 267 444 ± 246 449 ± 233 418 ± 213 505 ± 199 NS
IF 19 ± 11 24 ± 19 24 ± 16 24.3 ± 18 37 ± 17 NS
VEGF (pg/ml) Serum 4282 ± 3168 5103 ± 3309 1597 ± 1055 2514 ± 1545 3663 ± 1391 NS
IF 1597 ± 1631 2654 ± 3044 717 ± 1071 1465 ± 2305 NM NS
  1. All values represent mean ± SD. IF Interstitial fluid, NM not measurable, NS no statistical significant difference. 1Significance between 73 h and all other time points; 2significance between 73 and 49 h and 7 h; 3significance between 25 and 7 h; 4significance between 73 and 7 h; 5significance between 73, 49, and 25 h and 7 h