Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study

Table 3 Biological data during therapeutic hypothermia and rewarming

Biological parameters	Therapeutic hypothermia, hours after birth					Rewarming
Biological parameters	7 h	13 h	25 h	49 h	73 h	97 h
pH	7.1 ± 0.2	7.3 ± 0.1	7.3 ± 0.1	7.3 ± 0.1	7.3 ± 0.1	7.3 ± 0.1
pCO₂ (kPa)	6.5 ± 2.7	5.8 ± 1.7	5.5 ± 1.0	5.7 ± 1.0	6.0 ± 1.1	6.1 ± 1.2
BE (mmol/l) (−)	12.4 ± 5.1	6.5 ± 3.7	6.7 ± 3.2	5.8 ± 4.1	4.6 ± 2.9	3.5 ± 1.7
Hemoglobin (g/dl)	15.6 ± 2.2	15.4 ± 1.3	15.8 ± 1.8	15.1 ± 1.8	14.4 ± 1.6	13.5 ± 1.7
WBC (× 10⁹/l)	23.7 ± 13.2^{1, 2}	24.8 ± 12.7^{3, 4}	19.0 ± 7.9	14.9 ± 6.1	11.6 ± 5.5	10.7 ± 3.5
ANC (× 10⁹/l)	12.8 ± 10.4	15.5 ± 7.2^{3, 4}	13.8 ± 6.3^{5, 6}	10.1 ± 4.8	6.4 ± 2.2	6.9 ± 2.8
Lymph. (× 10⁹/l)	8.7 ± 5.5¹	4.1 ± 2.7	3.3 ± 1.7	3.4 ± 1.5	2.9 ± 0.7	2.6 ± 0.7
Mono. (× 10⁹/l)	1.5 ± 1.2	2.1 ± 1.2^{3, 4}	1.6 ± 0.9⁶	1.0 ± 0.6	0.7 ± 0.4	0.7 ± 0.4
Thrombocytes (× 10⁹/l)	217.0 ± 78.9	178.1 ± 57.8	158.9 ± 63.7	165.2 ± 80.3	143.3 ± 75.6	148.2 ± 75.5
CRP (mg/l)	15.6 ± 13.5	11.0 ± 13.5	10.7 ± 10.7	15.0 ± 12.4	23.6 ± 21.6	23.0 ± 28.7
s-glucose (mmol/l)	11.0 ± 4.8	10.1 ± 6.1	8.1 ± 6.6	5.7 ± 1.0	5.8 ± 2.3	5.3 ± 0.9
s-creatine (mcmol/l)	78.1 ± 16.1	86.9 ± 21.2	81.7 ± 32.1	86.5 ± 46.3	91.3 ± 67.9	85.0 ± 80.7
s-sodium (mmol/l)	135.8 ± 3.2	126.4 ± 32.2	133.9 ± 3.0	134.7 ± 4.0	135.2 ± 5.1	135.9 ± 6.2
s-potassium (mmol/l)	4.3 ± 0.7	4.2 ± 0.7	4.1 ± 0.8	4.0 ± 0.5	4.0 ± 0.6	4.2 ± 0.7
s-albumin (g/l)	28.8 ± 3.6⁷			25.7 ± 3.8

All values represent the mean ± SD. WBC White blood cell count, ANC Absolute neutrophil count, Lymph Lymphocytes, Mono Monocytes, CRP C-reactive protein, ¹P < 0.05 at 0–7 h vs. at 73–97 h, ²P < 0.05 at 0–7 h vs. at 49–73 h, ³P < 0.05 at 7–13 h vs. at 74–97 h, ⁴P < 0.05 at 7–13 h vs. at 49–73 h, ⁵P < 0.05 at 13–25 h vs. at 74–97 h, ⁶P < 0.05 at 13–25 h vs. at 49–73 h, ⁷P = 0.049 at 0–25 h vs. at 49–97 h

ISSN: 1471-2431