Table 1 Criteria for inclusion of therapeutic hypothermia
Inclusion criteria | Exclusion Criteria |
|---|---|
A: Gestational age ≥ 36 weeks | Expected need for surgical treatment (before 3 days of age) |
B: At least one of the following: | Severe birth defects with expected poor prognosis |
1. Apgar score ≤ 5 at 10 min after birth | |
2. Requires positive pressure ventilation 10 min after birth | |
3. pH < 7.00 in umbilical arterial blood or arterial blood within 60 min after birth | |
4. Base excess ≤ − 16 in umbilical arterial blood or arterial blood within 60 min after birth | |
C: Signs of moderate to severe encephalopathy with at least one of the following: | Age > 6 h before hypothermia could be initiated |
1. Hypotonia | |
2. Abnormal reflexes or constricted/deviated, dilated, nonreactive to light pupils | |
3. Weak or absent sucking reflex | |
4. Presence of seizures |