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Table 1 Criteria for inclusion of therapeutic hypothermia

From: Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study

Inclusion criteria Exclusion Criteria
A: Gestational age ≥ 36 weeks Expected need for surgical treatment (before 3 days of age)
B: At least one of the following: Severe birth defects with expected poor prognosis
1. Apgar score ≤ 5 at 10 min after birth
2. Requires positive pressure ventilation 10 min after birth
3. pH < 7.00 in umbilical arterial blood or arterial blood within 60 min after birth
4. Base excess ≤ − 16 in umbilical arterial blood or arterial blood within 60 min after birth
C: Signs of moderate to severe encephalopathy with at least one of the following: Age > 6 h before hypothermia could be initiated
1. Hypotonia
2. Abnormal reflexes or constricted/deviated, dilated, nonreactive to light pupils
3. Weak or absent sucking reflex
4. Presence of seizures