Table 2 Clinical characteristics of described patients with difficult asthma
From: Pediatric severe asthma: a case series report and perspectives on anti-IgE treatment
Case 1 | Case 2 | Case 3 | Case 4 | |
|---|---|---|---|---|
Age at asthma symptoms onset | 3 years | 6 years | 3 years | 4 years |
History | Monthly asthma exacerbations/ hospital admissions | Monthly asthma exacerbations/ hospital admissions | Monthly asthma exacerbations/ hospital admissions | Monthly asthma exacerbations/ hospital admissions |
Frequent need of systemic steroids | Frequent need of systemic steroids | Several ICU admissions | Frequent need of systemic steroids | |
Frequent need of systemic steroids | ||||
Allergen sensitization | House dust mites, dog dander, Graminaceae pollen mix, Parietaria judaica | House dust mites | House dust mites, dog and cat dander, Alternaria alternata, Graminaceae pollen mix, Artemisia vulgaris, Parietaria judaica, Olea europaea pollen, cow milk proteins, egg, peanuts | House dust mites, dog dander, Graminaceae pollen mix, Olea europaea pollen, tomatoes, beans, shrimps, peas |
Age at referral | 11 years | 10 years | 6 years | 8 years |
Comorbidity | Rhinosinusitis | GER | Absent | Absent |
Treatment at referral | Fluticasone (1000 μg/d) + salmeterol + montelukast | Fluticasone (1000 μg/d) + salmeterol + montelukast | Fluticasone (1000 μg/d) + salmeterol + montelukast | Fluticasone (1000 μg/d) + salmeterol + montelukast |