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Table 4 Changes in NSE levels after 3 days of treatment in children with HIE

From: Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

∆NSE
Group Time window Mild Moderate Severe
N Mean ± SD N Mean ± SD N Mean ± SD
Control group < 6 h 14 4.0 ± 0.6 14 19.1 ± 2.4b1 13 12.1 ± 0.3c1
≥ 6 h 13 5.2 ± 1.5 9 21.4 ± 3.6b2 9 16.8 ± 5.2c2
Hypothermia group < 6 h 15 2.0 ± 0.8 10 13.7 ± 1.8b1 6 14.3 ± 3.9c1
≥ 6 h 9 3.9 ± 2.8 7 15.3 ± 5.1b2 5 19.8 ± 1.9c2
P 0.35a < 0.01b < 0.05c
  1. ∆ Before and after treatment; ano statistically significant difference between mild HIE groups (P > 0.05), bmoderate HIE groups showed statistically significant differences (P < 0.01): b1moderate HIE and < 6 h subgroup (P < 0.05), b2 moderate HIE and 6-12 h subgroup (P < 0.05); csevere HIE patients showed statistically significant differences between the subgroups (P < 0.05): c1severe HIE and < 6 h subgroup (P < 0.05) c2severe HIE and 6-12 h subgroup (P > 0.05); two initiation time windows in the hypothermia group showed no difference in moderate HIE patients (b1b2 HIE; P > 0.05) but in severe HIE patients (c1c2 P < 0.05)
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