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Table 4 Changes in NSE levels after 3 days of treatment in children with HIE

From: Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

∆NSE

Group

Time window

Mild

Moderate

Severe

N

Mean ± SD

N

Mean ± SD

N

Mean ± SD

Control group

< 6 h

14

4.0 ± 0.6

14

19.1 ± 2.4b1

13

12.1 ± 0.3c1

≥ 6 h

13

5.2 ± 1.5

9

21.4 ± 3.6b2

9

16.8 ± 5.2c2

Hypothermia group

< 6 h

15

2.0 ± 0.8

10

13.7 ± 1.8b1

6

14.3 ± 3.9c1

≥ 6 h

9

3.9 ± 2.8

7

15.3 ± 5.1b2

5

19.8 ± 1.9c2

P

0.35a

< 0.01b

< 0.05c

  1. ∆ Before and after treatment; ano statistically significant difference between mild HIE groups (P > 0.05), bmoderate HIE groups showed statistically significant differences (P < 0.01): b1moderate HIE and < 6 h subgroup (P < 0.05), b2 moderate HIE and 6-12 h subgroup (P < 0.05); csevere HIE patients showed statistically significant differences between the subgroups (P < 0.05): c1severe HIE and < 6 h subgroup (P < 0.05) c2severe HIE and 6-12 h subgroup (P > 0.05); two initiation time windows in the hypothermia group showed no difference in moderate HIE patients (b1b2 HIE; P > 0.05) but in severe HIE patients (c1c2 P < 0.05)