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Table 3 Changes in aEEG scores after 3 days of treatment in children with HIE

From: Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

∆aEEG

Group

Time window

Mild

Moderate

Severe

N

Mean ± SD

N

Mean ± SD

N

Mean ± SD

Control group

< 6 h

13

3.6 ± 2.2

15

4.7 ± 1.7b1

13

3.0 ± 2.1c1

≥ 6 h

13

3.7 ± 2.2

10

3.7 ± 3.4b2

11

2.1 ± 1.4c2

Hypothermia group

< 6 h

14

4.5 ± 2.3

9

1.8 ± 0.7b1

5

0.2 ± 0.4c1

≥ 6 h

11

4.1 ± 2.7

8

2.1 ± 1.0b2

5

1.0 ± 0.7c2

P

0.76a

< 0.005b

< 0.05c

  1. ∆ Before and after treatment; ano statistically significant difference between mild HIE groups (P > 0.05), bmoderate HIE groups showed statistically significant differences (P < 0.01): b1moderate HIE and < 6 h subgroup (P < 0.05), b2 moderate HIE and 6-12 h subgroup (P < 0.05); c severe HIE patients showed statistically significant differences between the subgroups (P < 0.05): c1severe HIE and < 6 h subgroup (P < 0.05) c2severe HIE and 6-12 h subgroup (P > 0.05); two initiation time windows in the hypothermia group showed no difference in moderate HIE patients (b1b2 HIE; P > 0.05) but in severe HIE patients (c1c2 P < 0.05)