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Table 3 Changes in aEEG scores after 3 days of treatment in children with HIE

From: Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

∆aEEG
Group Time window Mild Moderate Severe
N Mean ± SD N Mean ± SD N Mean ± SD
Control group < 6 h 13 3.6 ± 2.2 15 4.7 ± 1.7b1 13 3.0 ± 2.1c1
≥ 6 h 13 3.7 ± 2.2 10 3.7 ± 3.4b2 11 2.1 ± 1.4c2
Hypothermia group < 6 h 14 4.5 ± 2.3 9 1.8 ± 0.7b1 5 0.2 ± 0.4c1
≥ 6 h 11 4.1 ± 2.7 8 2.1 ± 1.0b2 5 1.0 ± 0.7c2
P 0.76a < 0.005b < 0.05c
  1. ∆ Before and after treatment; ano statistically significant difference between mild HIE groups (P > 0.05), bmoderate HIE groups showed statistically significant differences (P < 0.01): b1moderate HIE and < 6 h subgroup (P < 0.05), b2 moderate HIE and 6-12 h subgroup (P < 0.05); c severe HIE patients showed statistically significant differences between the subgroups (P < 0.05): c1severe HIE and < 6 h subgroup (P < 0.05) c2severe HIE and 6-12 h subgroup (P > 0.05); two initiation time windows in the hypothermia group showed no difference in moderate HIE patients (b1b2 HIE; P > 0.05) but in severe HIE patients (c1c2 P < 0.05)
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