Skip to main content

Table 2 Anticoagulant therapy [4, 11, 13]

From: NEOnatal Central-venous Line Observational study on Thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related thrombosis

LMWH

Therapeutic dose

Monitoring

Nadroparin

 0 – 2 m

Enoxaparin

 0 – 2 m

Dalteparin

 0 – 2 m

Tinzaparin

 0 – 2 m

120-150 U/kg/12 h sc

1,7 mg/kg/12 h sc in preterm neonates

1,5 mg/kg/12 h sc in term neonates

150 U/kg/12 h sc

275 U/kg/24 h sc

Check anti-FXa level 4 h after 2nd dose;

Target anti-FXa level: 0.5–1.0 U/mL

Check platelets regularly

  1. Abbreviations: LMWH low-moleculair-weight heparin, h hour, m months, sc subcutaneously