Fig. 2

FISH analysis on interphase chromosomes of the proband. a) FISH image of the proband showing two hybridization signals on 16p13 region (green) and three hybridization signals on 16q22 region (red). b) Ideogram of the chromosome 16 indicating the hybridization points of the FISH probes, 16p13 including the MYH11 gene (spectrum green) and 16q22 including the CBFB gene (spectrum red) (Metasystems, Altlussheim, Germany). c) Partial karyogram of the proband indicating the hybridization points in the two chromosomes 16 and the derivative chromosome 15