Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury

Table 5 Bootstrap ratios of predictors and outcomes for the three Partial Least Square analyses

Variables	PLS 1	PLS 2	PLS 3
Age at Injury	−0.02	−1.32	−1.86
Sex	−2.32	−2.22	−0.94
GCS	0.67	1.54	0.42
SES	−1.90	−0.61	−1.23
PIFOS Total Score	−0.52	−0.25	1.53
PIFOS Cognition Score	0.39	0.60	3.09*
S100B	1.76	1.40	−0.31
NSE	3.20*	3.17*	3.98*
IL-6	0.78	−0.02	0.62
IL-8	0.43	−0.01	0.97
sVCAM	2.10	1.77	2.20
sNCAM	−2.81*	−2.04	−4.19*
Conners-3 Content Scales
Inattention	4.25*	-	-
Hyperactivity/Impulsivity	3.23*	-	-
Executive Functioning	3.09*	-	-
Learning Problems	−0.01	-	-
Defiance/Aggression	0.06	-	-
Peer Relations	−0.13	-	-
BRIEF BRI Scales
Inhibit	-	3.30*	-
Shift	-	0.06	-
Emotional Control	-	1.92	-
BRIEF MI Scales
Initiate	-	-	3.91*
Working Memory	-	-	6.72*
Plan/Organize	-	-	0.94
Organization of Materials	-	-	−1.04
Monitor	-	-	0.52

The bootstrap ratios are presented for the three Partial Least Squares (PLS) analyses conducted. The bootstrap ratios (z-scores) for the predictor variables are presented in the top half of the table, while the bootstrap ratios for the outcome variables are presented in the bottom half of the table. *Signifies significant differences between the latent variable and the null hypothesis

ISSN: 1471-2431