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Table 3 Screening Indices for Cord Blood G6PD Assay at two cut-off values

From: Screening for glucose-6-phosphate dehydrogenase deficiency in neonates: a comparison between cord and peripheral blood samples

 

Cut-off values

5.7 U/g Hb

8.05 U/g Hb

Sensitivity

98.6%a

90%

(CI:91.2, 99.9)

(CI:81.4, 95)

Specificity

99.7%

98.4%

(CI:99.1%, 99.9%)

(CI:97.4%, 99%)

Positive Predictive Value

94.5%

81%

(CI:85.8%, 98.2%)

(CI:71.7%, 87.9%)

Negative Predictive Value

99.5%

99.2%

(CI:99.5%, 100%)

(CI:98.5%, 99.6%)

Accuracy

99.6%

97.77%

  1. CI Confidence intervals
  2. a98.6% of all the patients with truly deficient peripheral G6PD assays had deficient cord blood results with cut-off 5.7 U/g Hb once compared to 8.05 U/g Hb