Skip to main content

Table 2 Evaluation of birth and early hospital characteristics of infants with late PH

From: Early characteristics of infants with pulmonary hypertension in a referral neonatal intensive care unit

Birth/early hospital characteristics

Infants with Late PH, n = 59

Infants without Late PH, n = 497

Odds ratio (95% CI)

p - value

Apgar 1 min.

Mean ± SD

3.5 ± 2.8

4.1 ± 2.6

0.9 (0.8–1.0)

0.10

Apgar 5 min.

Mean ± SD

6.3 ± 2.4

6.5 ± 2.2

1.0 (0.8–1.1)

0.44

Birthweight (kg)

Mean ± SD

0.75 ± 0.24

0.83 ± 0.25

0.2 (0.1–0.7)

0.02*

Gestational age (wks)

Mean ± SD

26.1 ± 2.4

26.1 ± 2.2

1.0 (0.9–1.1)

0.99

Mode of Delivery (n, %)

 C/S

44, 77%

327, 66%

1.7 (0.9–3.3)

0.10

 Vaginal

13, 23%

166, 34%

ref

 

Gender (n, %)

 Male

33, 56%

289, 42%

0.9 (0.5–1.6)

0.71

 Female

26, 44%

205, 42%

ref

 

Intrauterine growth restriction (n, %)

10, 18%

35, 7%

2.9 (1.3–6.2)

< 0.01*

Placental abruption (n, %)

9, 16%

49, 10%

1.7 (0.8–3.7)

0.17

Chorioamnionitis (n, %)

3, 5%

50, 10%

0.5 (0.2–1.7)

0.27

Maternal betamethasone (n, %)

 2 or more doses

27, 57%

267, 62%

0.8 (0.4–1.5)

0.52

 0–1 doses

20, 43%

162, 38%

ref

 

Race (n, %)

 Black

36, 61%

290, 60%

1.1 (0.6–1.8)

0.84

 White/Asian/Hispanic

23, 39%

196, 40%

ref

 

Illicit drug use (n, %)

3, 6%

41, 9%

0.6 (0.2–2.2)

0.47

Multiples (n, %)

12, 21%

91, 18%

1.2 (0.6–2.3)

0.68

Maternal drug use

5, 10%

39, 9%

1.2 (0.4–3.1)

0.76

Caffeine (n, %)

29, 51%

341, 69%

0.5 (0.3–0.8)

< 0.01*

Any respiratory support, 28 days (n, %)

26, 44%

212, 43%

1.0 (0.6–1.8)

0.87

Positive pressure ventilation, 28 days (n,%)

26, 44%

203, 41%

1.1 (0.7–2.0)

0.63

Any respiratory support, 36 weeks (n, %)

26, 44%

199, 40%

1.2 (0.7–2.2)

0.45

Sildenafil (n, %)

11, 19%

19, 4%

5.8 (2.6–12.8)

< 0.01*

Bosentan

2, 3%

0, 0%

__________

_____

  1. The birth and early hospital characteristics of infants who had late PH were compared to those infants who did not have late PH using univariable logistic regression. Odds ratios were defined using univariable logistic regression, *p < 0.05 is significant