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Table 4 Associations between infant weight gain and allergic outcomes by 36 months

From: Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Quartile 1

Quartile 2

Quartile 3

Quartile 4

 

Period of weight gain

Allergic outcomes

N (%)

N (%)

N (%)

N (%)

Reference

group

Adjusted OR (95% CI)

Adjusted OR (95% Adjusted OR

CI) (95% CI)

Adjusted OR (95% Adjusted

p-trend

0 to 3 months

Wheeze with a positive skin prick test

11 (6.7)

15 (9.3)

19 (11.8)

19 (13.1)

1.00

1.6 (0.6–4.5)

1.8 (0.6–5.4)

1.3 (0.4–4.0)

0.7

Rhinitis with a positive skin prick test

10 (6.7)

9 (6.3)

16 (10.6)

24 (17.6)

1.00

0.9 (0.3–3.1)

1.3 (0.4–4.3)

1.7 (0.5–6.0)

0.3

Atopic eczema with a positive skin prick test

5 (3.4)

10 (6.7)

9 (6.6)

10 (7.3)

1.00

1.9 (0.5–7.1)

1.4 (0.3–5.8)

1.1 (0.3–4.9)

0.9

Positive skin prick test

34 (17.4)

36 (20.0)

45 (24.7)

59 (31.7)

1.00

1.3 (0.7–2.6)

1.6 (0.8–3.3)

1.6 (0.8–3.3)

0.2

3 to 6 months

Wheeze with a positive skin prick test

12 (7.6)

14 (8.4)

7 (4.5)

16 (11.0)

1.00

1.3 (0.4–3.9)

0.3 (0.1–1.5)

2.6 (0.9–7.3)

0.2

Rhinitis with a positive skin prick test

9 (6.3)

22 (14.7)

10 (7.0)

13 (10.3)

1.00

6.7 (1.4–31.8)

3.2 (0.6–16.4)

4.5 (0.9–22.2)

0.3

Atopic eczema with a positive skin prick test

7 (4.9)

6 (4.0)

2 (1.4)

7 (5.3)

1.00

0.8 (0.2–3.1)

0.2 (0.0–1.6)

1.0 (0.3–3.8)

0.8

Positive skin prick test

43 (23.8)

41 (22.7)

46 (25.8)

35 (21.1)

1.00

1.1 (0.6–2.2)

1.1 (0.6–2.1)

0.9 (0.5–1.8)

0.8

6 to 9 months

Wheeze with a positive skin prick test

12 (7.6)

11 (6.7)

13 (8.5)

8 (5.3)

1.00

0.4 (0.1–1.4)

0.7 (0.2–2.0)

1.1 (0.3–3.5)

0.9

Rhinitis with a positive skin prick test

12 (8.3)

13 (9.2)

12 (8.6)

9 (7.1)

1.00

0.5 (0.1–1.8)

0.6 (0.2–2.0)

0.5 (0.1–1.9)

0.3

Atopic eczema with a positive skin prick test

6 (4.2)

7 (5.1)

4 (3.0)

2 (1.6)

1.00

1.4 (0.4–5.8)

0.8 (0.2–3.6)

0.7 (0.1–4.3)

0.6

Positive skin prick test

40 (23.3)

45 (25.9)

37 (22.2)

34 (20.4)

1.00

0.5 (0.3–0.96)

0.5 (0.3–1.0)

0.5 (0.3–1.0)

0.06

9 to 12 m o n th s

Wheeze with a positive skin prick test

14 (8.9)

7 (4.5)

8 (4.9)

9 (5.5)

1.00

0.5 (0.1–1.6)

0.7 (0.2–2.1)

0.2 (0.0–0.8)

0.04

Rhinitis with a positive skin prick test

11 (8.2)

8 (6.0)

9 (6.1)

17 (11.7)

1.00

0.5 (0.1–2.3)

0.7 (0.2–2.7)

1.2 (0.3–4.2)

0.7

Atopic eczema with a positive skin prick test

4 (2.9)

1 (0.7)

6 (4.6)

4 (2.9)

1.00

#

1.3 (0.3–5.7)

0.5 (0.1–3.1)

0.9

Positive skin prick test

43 (24.9)

39 (23.8)

37 (21.4)

39 (22.9)

1.00

0.9 (0.5–1.6)

0.8 (0.4–1.5)

0.5 (0.3–1.1)

0.1

12 to 15 months

Wheeze with a positive skin prick test

6 (3.6)

10 (6.0)

8 (4.8)

8 (4.6)

1.00

1.7 (0.5–5.5)

0.5 (0.1–2.1)

1.1 (0.3–4.0)

0.6

Rhinitis with a positive skin prick test

8 (6.1)

15 (10.7)

11 (7.6)

9 (6.0)

1.00

1.3 (0.3–5.2)

1.3 (0.3–5.1)

0.8 (0.2–3.3)

0.7

Atopic eczema with a positive skin prick test

4 (2.7)

5 (3.3)

2 (1.4)

3 (1.9)

1.00

1.3 (0.3–6.3)

#

0.8 (0.1–5.4)

0.3

Positive skin prick test

49 (27.8)

40 (23.1)

37 (20.9)

37 (20.6)

1.00

0.6 (0.3–1.0)

0.4 (0.2–0.8)

0.4 (0.2–0.8)

<0.01

  1. Weight gain at 0–3 months adjusted for birthweight for gestational age and sex, family history of allergy, ethnicity, gestational age, sex, breastfeeding, maternal education levels, maternal height and maternal BMI. Weight gain (Kg) at 3–6 months, 6–9 months, 9–12 months and 12–15 months were adjusted for the baseline weight at the beginning of the period, family history of allergy, ethnicity, sex, breastfeeding, maternal education levels, maternal height and maternal BMI
  2. #Not estimable, owing to insufficient number of children with studied outcomes
  3. Values in italics have reached statistical significance with p-value <0.5