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Table 4 Associations between infant weight gain and allergic outcomes by 36 months

From: Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life

  Quartile 1 Quartile 2 Quartile 3 Quartile 4 Quartile 1 Quartile 2 Quartile 3 Quartile 4  
Period of weight gain Allergic outcomes N (%) N (%) N (%) N (%) Reference
group
Adjusted OR (95% CI) Adjusted OR (95% Adjusted OR
CI) (95% CI)
Adjusted OR (95% Adjusted p-trend
0 to 3 months Wheeze with a positive skin prick test 11 (6.7) 15 (9.3) 19 (11.8) 19 (13.1) 1.00 1.6 (0.6–4.5) 1.8 (0.6–5.4) 1.3 (0.4–4.0) 0.7
Rhinitis with a positive skin prick test 10 (6.7) 9 (6.3) 16 (10.6) 24 (17.6) 1.00 0.9 (0.3–3.1) 1.3 (0.4–4.3) 1.7 (0.5–6.0) 0.3
Atopic eczema with a positive skin prick test 5 (3.4) 10 (6.7) 9 (6.6) 10 (7.3) 1.00 1.9 (0.5–7.1) 1.4 (0.3–5.8) 1.1 (0.3–4.9) 0.9
Positive skin prick test 34 (17.4) 36 (20.0) 45 (24.7) 59 (31.7) 1.00 1.3 (0.7–2.6) 1.6 (0.8–3.3) 1.6 (0.8–3.3) 0.2
3 to 6 months Wheeze with a positive skin prick test 12 (7.6) 14 (8.4) 7 (4.5) 16 (11.0) 1.00 1.3 (0.4–3.9) 0.3 (0.1–1.5) 2.6 (0.9–7.3) 0.2
Rhinitis with a positive skin prick test 9 (6.3) 22 (14.7) 10 (7.0) 13 (10.3) 1.00 6.7 (1.4–31.8) 3.2 (0.6–16.4) 4.5 (0.9–22.2) 0.3
Atopic eczema with a positive skin prick test 7 (4.9) 6 (4.0) 2 (1.4) 7 (5.3) 1.00 0.8 (0.2–3.1) 0.2 (0.0–1.6) 1.0 (0.3–3.8) 0.8
Positive skin prick test 43 (23.8) 41 (22.7) 46 (25.8) 35 (21.1) 1.00 1.1 (0.6–2.2) 1.1 (0.6–2.1) 0.9 (0.5–1.8) 0.8
6 to 9 months Wheeze with a positive skin prick test 12 (7.6) 11 (6.7) 13 (8.5) 8 (5.3) 1.00 0.4 (0.1–1.4) 0.7 (0.2–2.0) 1.1 (0.3–3.5) 0.9
Rhinitis with a positive skin prick test 12 (8.3) 13 (9.2) 12 (8.6) 9 (7.1) 1.00 0.5 (0.1–1.8) 0.6 (0.2–2.0) 0.5 (0.1–1.9) 0.3
Atopic eczema with a positive skin prick test 6 (4.2) 7 (5.1) 4 (3.0) 2 (1.6) 1.00 1.4 (0.4–5.8) 0.8 (0.2–3.6) 0.7 (0.1–4.3) 0.6
Positive skin prick test 40 (23.3) 45 (25.9) 37 (22.2) 34 (20.4) 1.00 0.5 (0.3–0.96) 0.5 (0.3–1.0) 0.5 (0.3–1.0) 0.06
9 to 12 m o n th s Wheeze with a positive skin prick test 14 (8.9) 7 (4.5) 8 (4.9) 9 (5.5) 1.00 0.5 (0.1–1.6) 0.7 (0.2–2.1) 0.2 (0.0–0.8) 0.04
Rhinitis with a positive skin prick test 11 (8.2) 8 (6.0) 9 (6.1) 17 (11.7) 1.00 0.5 (0.1–2.3) 0.7 (0.2–2.7) 1.2 (0.3–4.2) 0.7
Atopic eczema with a positive skin prick test 4 (2.9) 1 (0.7) 6 (4.6) 4 (2.9) 1.00 # 1.3 (0.3–5.7) 0.5 (0.1–3.1) 0.9
Positive skin prick test 43 (24.9) 39 (23.8) 37 (21.4) 39 (22.9) 1.00 0.9 (0.5–1.6) 0.8 (0.4–1.5) 0.5 (0.3–1.1) 0.1
12 to 15 months Wheeze with a positive skin prick test 6 (3.6) 10 (6.0) 8 (4.8) 8 (4.6) 1.00 1.7 (0.5–5.5) 0.5 (0.1–2.1) 1.1 (0.3–4.0) 0.6
Rhinitis with a positive skin prick test 8 (6.1) 15 (10.7) 11 (7.6) 9 (6.0) 1.00 1.3 (0.3–5.2) 1.3 (0.3–5.1) 0.8 (0.2–3.3) 0.7
Atopic eczema with a positive skin prick test 4 (2.7) 5 (3.3) 2 (1.4) 3 (1.9) 1.00 1.3 (0.3–6.3) # 0.8 (0.1–5.4) 0.3
Positive skin prick test 49 (27.8) 40 (23.1) 37 (20.9) 37 (20.6) 1.00 0.6 (0.3–1.0) 0.4 (0.2–0.8) 0.4 (0.2–0.8) <0.01
  1. Weight gain at 0–3 months adjusted for birthweight for gestational age and sex, family history of allergy, ethnicity, gestational age, sex, breastfeeding, maternal education levels, maternal height and maternal BMI. Weight gain (Kg) at 3–6 months, 6–9 months, 9–12 months and 12–15 months were adjusted for the baseline weight at the beginning of the period, family history of allergy, ethnicity, sex, breastfeeding, maternal education levels, maternal height and maternal BMI
  2. #Not estimable, owing to insufficient number of children with studied outcomes
  3. Values in italics have reached statistical significance with p-value <0.5