Table 1 Covariates included in the Cox proportionate hazards analysis of time to persistent confirmed autoantibody positivity
Fixed Covariates | Hazard Ratio (95% CI) | Wald test p-valuea | |
|---|---|---|---|
First-Degree Relative (Ref = No) | 2.51 (2.06, 3.30) | <0.001 | |
HLA (Ref = DR3/DR4) | |||
DR4/DR4 | 0.69 (0.54, 0.88) | 0.003 | |
DR4/DR8 | 0.70 (0.54, 0.91) | 0.008 | |
DR3/DR3 | 0.46 (0.35, 0.60) | <0.001 | |
All Others | 0.46 (0.29, 0.72) | <0.001 | |
Gender (Ref = male) | 0.77 (0.65, 0.92) | 0.003 | |
SNP | |||
RS1004446_a | 0.84 (0.74, 0.96) | 0.010 | |
RS10517086_a | 1.14 (1.00, 1.31) | 0.050 | |
RS12708716_g | 0.87 (0.76, 0.99) | 0.034 | |
RS2292239_a | 1.24 (1.09, 1.41) | <0.001 | |
RS2476601_a | 1.55 (1.31, 1.83) | <0.001 | |
RS2816316_c | 1.07 (0.91, 1.25) | 0.429 | |
RS3184504_a | 1.33 (1.17, 1.50) | <0.001 | |
RS4948088_a | 0.74 (0.53, 1.04) | 0.086 | |
Ever Breastfed (Ref = No) | 1.96 (1.01, 3.81) | 0.042 | |
Probiotics <3 Mo Age (Ref = No) | 0.72 (0.55, 0.94) | 0.015 | |
Time Dependent Covariates | |||
Cumulative Number of Infections | 1.02 (0.99, 1.03) | 0.407 | |
Cumulative Weeks Analgesic Use | 1.02 (0.99, 1.04) | 0.269 | |