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Table 2 Logistic regression models examining the association between maternal chorioamnionitis and neonatal respiratory outcomes and perinatal death in preterm infants

From: Neonatal respiratory morbidity following exposure to chorioamnionitis

 

Traditional approach

Fetuses-at-risk approachb

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

 

BPD

BPD or Perinatal mortality

BPD

BPD or Perinatal mortality

Crude Model

5.61 (4.79–6.58)

2.73 (2.42–3.09)

8.79 (7.53–10.26)

4.22 (3.76–4.73)

Adjusted Modela

1.34 (1.09–1.66)

1.23 (1.01–1.50)

6.25 (5.25–7.44)

5.18 (4.39–6.11)

 

RDS

RDS or Perinatal Mortality

RDS

RDS or Perinatal Mortality

Crude Model

2.62 (2.39–2.87)

2.45 (2.25–2.68)

3.75 (3.46–4.07)

3.43 (3.19–3.70)

Adjusted Modela

0.99 (0.87–1.13)

0.98 (0.86–1.12)

2.78 (2.54–3.06)>

2.74 (2.50–3.01)

  1. aOther potential confounders include: diabetes, hypertension, infant sex, maternal age, maternal race, mode of delivery, antenatal steroids. Traditional models are also adjusted for gestational age at delivery
  2. bThe fetuses-at-risk model included all fetuses-at-risk of respiratory outcomes and perinatal death (n = 763,671)
  3. BPD bronchopulmonary dysplasia, RDS respiratory distress syndrome