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Table 2 Risk on infant death in term ans preterm newborns: all cases, isolated CHDa and isolated majour CHDb

From: Impact of preterm birth on infant mortality for newborns with congenital heart defects: The EPICARD population-based cohort study

  

Term

Preterm

  
  

%

95% CI

%

95% CI

RR

95% CI

All cases

 

N = 1876

N = 296

  

Neonatal mortality

early <7 days

1.5

1.0–2.1

6.1

3.6–9.4

4.1

2.3–7.3

 

7.3late 7-28d

1.2

0.8–1.8

5.7

3.4–9.0

4.7

2.5–8.7

 

Total

2.7

2.0–3.6

11.8

8.4–16.1

4.3

2.9–6.6

Post neonatal mortality

28d-3 months

0.9

0.5–1.4

2.4

1.0–4.8

2.8

1.2–6.7

 

3 m-1y

1.2

0.7–1.8

3.7

1.9–6.6

3.2

1.6–6.5

 

Total

2.1

1.4–2.8

6.1

3.6–9.4

3.0

1.7–5.2

Infant mortality

<1 year

4.8

3.8–5.8

17.9

13.7–22.8

3.8

2.7–5.2

Isolated CHDa

 

N = 1551

N = 200

  

Neonatal mortality

early <7 days

1.0

0.5–1.6

3.0

1.1–6.4

3.1

1.2–7.9

 

7.9late 7-28d

0.8

0.5–1.4

2.5

0.8–5.7

3

1.1–8.3

 

Total

1.8

1.2–2.6

5.5

2.8–9.6

3.0

1.5–6.0

Post neonatal mortality

28d-3 months

0.5

0.2–1.0

1.5

0.3–4.3

2.9

0.8–10.8

 

3 m-1y

0.8

0.4–1.4

1.0

0.1–3.6

1.3

0.3–5.7

 

Total

1.3

0.8–2.0

2.5

0.8–5.7

1.9

0.7–5.1

Infant mortality

<1 year

3.1

2.2–4.0

8

4.6–12.8

2.6

1.5–4.5

Isolated major CHDb

 

N = 542

N = 114

  

Neonatal mortality

early <7 days

2.8

1.6–4.5

5.3

2.0–11.1

1.9

0.8–4.8

 

late 7-28d

2.4

1.3–4.1

4.4

1.4–9.9

1.8

0.7–5.0

 

Total

5.2

3.5–7.4

9.7

4.9–16.6

1.9

1.0–3.6

Post neonatal mortality

28d-3 months

1.5

0.6–2.9

2.6

0.6–7.5

1.8

0.5–6.6

 

3 m-1y

2

1.0–3.6

1.8

0.2–6.2

0.9

0.2–3.8

 

Total

3.5

2.1–5.4

4.4

1.4–9.9

1.3

0.5–3.3

Infant mortality

<1 year

8.7

6.4–11.4

14.1

8.2–21.8

1.6

1.0–2.8

  1. aIsolated CHD: excluding cases with chromosomal or other anomalies
  2. bIsolated major CHD: excluding cases with chromosomal or other anomalies and ventricular septal defects (VSD)