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Table 4 The comparison of studies in postnatal patients with isolate/syndromic CHD

From: Chromosome microarray analysis in the investigation of children with congenital heart disease

Study Array type No. tested Other diagnosis PCNVs rates VOUS rates
Thienpont et al. 2007 [9] 1 Mb BAC 60 MCA, ID 16.7% 11.7%
Richards et al. 2008 [11] 385 K oligo arrays 20 MCA, DD/ID 25% 9.8%
20 None 0
Erdogan et al. 2008 [10] 1 Mb BAC or 1 × 244 K Agilent arrays 105 None 4.7% Unknow
Greenway et al. 2009 [12] Affymetrix SNP 6.0 114 None 5.3% Unknow
Breckpot J et al. 2010 [13] 1 Mb array 150 MCA 17.3% Unknow
Rauch et al. 2010 [14] 100 K Affymetrix 19 MCA 21% Unknow
Goldmuntz et al. 2011 [16] 100 K Oligo array 58 MCA 20.7% 3.4%
Breckpot et al. 2011 [15] Affymetrix SNP 6.0 46 None 4.3% Unknow
Derwinska et al. 2012 [17] 180 K Oligo 150 MCA 14% Unknow
Syrmou et al. 2013 [19] 1 × 244 K or 4 × 180 K Agilent arrays 55 MCA 25.5% Unknow
Bachman et al. 2013 [18] Roche NimbleGen 135 K arrays 46 MCA 10.9% Unknow
Our study Affymetrix CytoScan HD arrays 104 MCA, ID/DD 27.9% 2.9%
  1. BAC bacterial artificial chromosome, MCA multiple congenital anomalies, DD/ID development delay/intellectual disabilities, SNP single nucleotide polymorphism