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Table 4 Prognostic factors associated with NEC reported in at least two studies

From: Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies

First author: Boo Carter Drenckpohl Faustini Gagliardi Gephart Guthrie Lee Luig Manogura Uauy Yamoto Yee Youn
(Low) birth weightb OR 0.999
[0.998,0.999]c
OR 1.001
[p = 0.164]d,e
OR 1
[1.000,1.001]
. . . p < 0.001f OR 0.07
[0.01,0.53]g
. p < 0.001f OR 0.999
[p < 0.001]c,d,h
. . .
Gestational age (weeks)b . . . . . OR 2.37
[1.78,3.16]i
. OR 1.14
[0.85,1.54]g
OR 0.82
[0.77,0.89]g
. . OR 19.32
[3.27,370.43]j
OR 0.84
[0.81,0.87]g
.
Sepsis . . OR 4.98
[2.2,11.27]a
. OR 5.38
[2.86,10.14]k
OR 1.49
[1.30,1.72]k
. OR 1.41
[0.42,4.67]a
. . . . . OR 1.75
[0.71,2.86]l
Ethnicity . OR 0.571
[p = 0.317]d,m
OR 0.36
[0.17,0.78]n
. . OR 1.22
[1.09,1.35]m
. . . . OR 1.68
[p < 0.001]d,h,m
. . .
Hypotension . . . . . OR 1.51
[1.36,1.69]o
. . . . . . . OR 2.00
[1.001,3.999]o
Outborn . . . . . OR 1.31
[1.17,1.46]
. . . . . . OR 1.55
[1.31,1.83]
.
Assisted ventilation . OR 1.053
[p = 0.047]d,a
. . OR 2.71
[1.03,7.15]a
. OR 3.5
[2.5,4.7]p
. . . . . . .
Cesarean section . . . . . . OR 0.60
[0.50,0.80]
. . . OR 0.60
[p < 0.001]d,h
. . .
PROM . . OR 2.06
[1.02,4.16]
. . . . . . . OR 1.10
[p < 0.009]d,h
. . .
Small for gestational ageb . . . . . . . . OR 1.97
[1.19,3.26]a
. . . OR 1.35
[1.08,1.69]q
.
Surfactant OR 1.59
[1.17,2.16]
. . . OR 0.41
[0.19,0.90]
. . . . . . . . .
  1. This table shows the strength and the direction of association of prognostic factors, with concomitant confidence intervals if available
  2. NEC necrotizing enterocolitis, OR odds ratio, PROM premature rupture of membranes
  3. Footnotes: a exact definition was lacking; b cutt-off values differs between studies; c < 1500 g; d no CI was given or could be calculated; e < 1500 g or requiring mechanical ventilation at birth; f OR increased with decreasing weight, no exact ratio was given; g calculated for increase of one unit of the continuous variable; h calculated by results presented in article; i < 28 weeks; j < 26 weeks; k late-onset sepsis; l combination of early- and late-onset sepsis; m black ethnicity; n white ethnicity; o inotropics requirement; p mechanical ventilation first day of life; q < 10th percentile for the given GA