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Table 2 Characteristics of IDRF-negative patients who underwent laparotomy or laparoscopic tumor resection

From: Laparoscopic resection of neuroblastomas in low- to high-risk patients without image-defined risk factors is safe and feasible

 

Laparotomy (n = 9)

Laparoscopic surgery (n = 7)

p

Risk

Low/intermediate 3 (33%)

High 6 (67%)

Low/intermediate 2 (29%)

High 5 (71%)

0.838

Surgery

total removal 9 (100%)

total removal 7 (100%)

 

Age (month) a

12 [9.5–48]

28 [23–51]

0.143

Sex

male 6 (67%)

female 3 (33%)

male 3 (43%)

female 4 (57%)

0.615

Body weight (kg) a

8.65 [8.09–15.2]

11.8 [10.3–14.9]

0.143

Kaup index a

15.32 [13.87–16.65]

15.67 [15.51–16.45]

0.626

MYCN amplified

amplified 2 (22%), single copy 2 (22%), unknown 5 (56%)

amplified 2 (29%), single copy 2 (29%), unknown 3 (43%)

0.771

VMA (mg/gCr) a

11.1 [9.6–17.0]

9.1 [7.8–19.8]

0.805

HVA (mg/gCr) a

21 [17.7–30.3]

18.2 [11.2–30.4]

0.805

NSE (ng/mL) a

9.6 [8.0–29.4]

19.3 [12.4–21.0]

0.326

Largest tumor dimension at surgery (cm) a

3.3 [2.9–4.1]

3.6 [2.7–5.0]

0.626

Duration of surgery (min) a

221 [130–304]

172 [122–253]

0.626

Loss of blood volume (mL/kg) a

5 [2.6–16]

2.1 [0.1–4.0]

0.037 b

Time to start postoperative feeding (days) a

4 [2–5]

3 [2–3]

0.023 b

Locoregional recurrence (1 year)

22%

0%

0.475

Progression-free survival (1 year)

78%

100%

0.414

Overall survival (1 year)

67%

100%

0.231

Follow up (months) a

81 [52–94]

21 [17–28]

 
  1. IDRF image-defined risk factor, MYCN N-myc proto-oncogene protein, VMA vanillylmandelic acid, HVA homovanillic acid, NSE neuron-specific enolase
  2. aMedian [Interquartile range] bSignificant differences