Premature atherosclerosis in children with beta-thalassemia major: New diagnostic marker

BMC Pediatrics

Table 2 Hematological and biochemical parameters of the studied groups

Parameter	Patients (N = 65)	Controls (N = 50)	Test	p-value
WBC (×10³/mm³)
Mean ± SD	11.3 ± 4.6	7.3 ± 1.8	MW = 2.5	0.013
Range	9 – 18.3	5 – 9	MW = 2.5	0.013
Hb (gm/dl)
Mean ± SD	6.8 ± 0.9	12.6 ± 0.7	t = −17.5	<0.001
Range	5 – 8.3	11.8 –14.2	t = −17.5	<0.001
PLT (×10³/mm³)
Mean ± SD	478.4 ± 279.4	276 ± 77.6	MW = 2.2	0.030
Range	136 – 1428	170 – 405	MW = 2.2	0.030
SGOT (IU/L)
Mean ± SD	52.3 ± 39.4	30.4 ± 6.8	MW = 2.74	0.020
Range	9 – 160	20 – 40	MW = 2.74	0.020
SGPT (IU/L)
Mean ± SD	46.4 ± 38.4	29.7 ± 6.8	MW = 2.36	0.020
Range	8 – 155	19 – 38	MW = 2.36	0.020
Total bilirubin (mg/dl)
Mean ± SD	1.4 ± 0.6	0.6 ± 0.2	MW = 3.84	0.001
Range	0.6 – 2.8	0.4 – 0.9	MW = 3.84	0.001
Direct bilirubin
Mean ± SD	0.2 ± 0.1	0.2 ± 0.1	MW = −0.147	0.885
Range	0.1 – 0.5	0.1 – 0.4	MW = −0.147	0.885
Total Proteins (gm/dl)
Mean ± SD	6.1 ± 1.3	6.8 ± 0.8	t = −1.462	0.154
Range	4.5 – 8	5.2 – 8	t = −1.462	0.154
Urea (mg/dl)
Mean ± SD	29.6 ± 6.9	27.5 ± 5.6	MW = −0.167	0.847
Range	21 – 41	15 – 37	MW = −0.167	0.847
Creatinine (mg/dl)
Mean ± SD	0.5 ± 0.3	0.4 ± 0.2	t = 0.341	0.766
Range	0.3 – 0.8	0.2 – 0.7	t = 0.341	0.766
CRP
Mean ± SD	5.7 ± 5.7	0.9 ± 0.9	MW = 2.6	0.012
Range	1 – 21	0 – 2	MW = 2.6	0.012
S. ferritin (ng/dl)
Mean ± SD	2490 ± 1579	83 ± 32	MW = 4.7	<0.001
Range	653 – 8406	30 – 127	MW = 4.7	<0.001

MW Mann Whitney U test, SGOT Aspartate transaminase, t independent Student t-test, SGPT Alanine transaminase, p < 0.05 is significant, CRP C- reactive protein

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