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Table 3 Differential PRF1 enhancer methylation according to characteristics of RSV bronchiolitis among all subjects (cases and controls combined)

From: Reduced PRF1 enhancer methylation in children with a history of severe RSV bronchiolitis in infancy: an association study

Characteristics

DNA methylation levels at the PRF1 enhancer

CpG E1

 

CpG E2

 

n

median (p25, p75)

p-value*

n

median (p25, p75)

p-value*

Gender

  

0.06

  

0.09

Female

30

74.8 (66.0, 83.0)

 

30

73.3 (67.0, 78.5)

 

Male

56

74.0 (60.0, 78.8)

 

56

70.8 (64.3, 74.5)

 

Gestational age

  

0.26

  

0.61

≥37 weeks

58

74.5 (67.5, 80.0)

 

58

70.8 (64.0, 75.0)

 

<37 weeks

11

73.5 (55, 75.5)

 

11

70.0 (55.0, 73.5)

 

Sibling status

  

0.34

  

0.25

None

11

75.5 (74.5, 84.5)

 

11

73.0 (70.0, 78.5)

 

≥1

55

74.5 (66.0, 80.0)

 

55

71.5 (64.0, 75.0)

 

Smoking in the household

  

0.003

  

0.004

No

43

75.5 (70.0, 83.2)

 

43

72.0 (67.0, 78.5)

 

Yes

29

69.5 (62.5, 76.0)

 

29

68.0 (63.0, 72.5)

 
  1. Differences in the total number of observations are due to missing data
  2. n number of observations, p25 25th percentile, p75 75th percentile
  3. *p-value calculated using Kruskal-Wallis test